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EC number: 611-084-9 | CAS number: 54041-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May-August 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- other: OSPAR Commission 2006 Part B. Protocol for a fish acute toxicity test
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all test concentrations and control sampled
- Sample storage conditions before analysis: below 5 °C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: FOE-hydroxy was characterised as poorly soluble and test solutions were therefore prepared by Water Accommodated Fractions (WAFs).
- Evidence of undissolved material (e.g. precipitate, surface film, etc): Floating particles - Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheephead minnow
- Age at study initiation: 10-15 weeks - Test type:
- semi-static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 20 +- 2°C
- pH:
- 7.98-8.19
- Dissolved oxygen:
- 96.1-99.9 %
- Salinity:
- 32.7-34.7 ‰
- Nominal and measured concentrations:
- Range finding test: Nominal noncentration (mg/L) 1, 10, 100 and 1000
Definitive test: Nominal concentrations (mg/L) 10, 18, 32, 56 and 100 , Analytical concentrations (mg/L) 10, 17, 32, 51, 91 - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers
- Type: open
- Material, size, headspace, fill volume: glass, 5 l in size, filled with 3 l test media(saltwater)
- Aeration: yes, througout test duration
- No. of organisms per vessel: 10
- Biomass loading rate: The maximum loading density cannot exceed 1g fish (wet weight) per litre of medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Natural local seawater is pumped to holding tanks from Scapa Flow, Orkney (Latitude 58°50'8.02"N, Longitude 3° 8'10.80"W). The treatment process includes sand filters to remove particulate matter, followed by a 1 µm filter. This water is heated to 20ºC, UV treated, degassed and held at a quantity of 3000 to 5000 litres. The treated seawater is constantly pumped through the Opus laboratory water system and trickle replenished as the water is used.
-Water/test medium change: at 48 h in all test concentrations.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: At least five test concentrations are used in a geometric series with a maximum factor of 1.8 or 3.2; concentrations will depend on range-finding test results.
- Range finding study
- Test concentrations: 1, 10, 100 and 1000 mg/L
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 23 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: none
- Other biological observations: none
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none - Validity criteria fulfilled:
- yes
- Conclusions:
- In the definitive test FOE-hydroxy exhibited a 96h-LC50 of 23 mg/L (Water Accommodated Fractions (WAFs)) to the marine fish Cyprinodon variegatus in the water phase. This test result is based on measured concentrations.
- Executive summary:
In the definitive test FOE-hydroxy exhibited a 96h-LC50 of 23 mg/L (Water Accommodated Fractions (WAFs)) to the marine fish Cyprinodon variegatus in the water phase. This test result is based on measured concentrations.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
- Details on sampling:
- Daily
- Vehicle:
- no
- Remarks:
- Use of ultrasonic bath (15 min.)
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Name: Zebra fish (Danio rerio)
- Source: West Aquarium GmbH (Germany)
- Date of birth: 04.11.1993
- Date supplied: 27.01.1994
- Temperature: 20-24 °C
- Mortalities during acclimatisation period: < 5 %
- Medication: none
- Keeping water: synthetic freshwater according to ISO - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 10.4 °dH
- Test temperature:
- 21.02 - 21.9 °C
- pH:
- 7.7 - 8.2
- Dissolved oxygen:
- 8.3 - 9.5 mg/L
- Nominal and measured concentrations:
- nominal: 35, 50, 71, 100, 141 and 200 mg/L
measured: 34.1, 49.1, 68.8, 96.5, 137.2, 195.2 mg/L (at the beginning), 34.8, 50.1, 70.2, 100.1, 139.0, 196.6 (at the end) - Details on test conditions:
- - Test vessels: glass aquaria holding 5 L of test media covered with glass plates
- Experimental design: 6 test concentration plus 1 control, 10 animals per test concentration
- no feeding during the exposure period
- static system
- Method of initiation: animals were placed in prepared media
- Photoperiod: 16 h light: 8 h dark
- Temperature: 21.2 to 21.9 °C
- Test item concentration/s: 35, 50, 71, 100, 141 and 200 mg/L(nominal concentration)
- Method of administration: direct weighing
- Medium renewal: none
- Duration of exposure: 96 hours
- Criteria of effects: The criterion of death used in this study was the absence of response to physical stimulation. In addition to observations on mortality at 0, 24, 48, 72 and 96 hours, type and incidence of sub-lethal effects compared with control fish were observed. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 49.6 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 127.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 195.9 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Remarks:
- mortality in control <= 10% (or one fish, if fewer than 10 control fish are tested); the dissolved oxygen concentration should be ≥60% of the air saturation value in all test vessels throughout the exposure;
- Conclusions:
- An 96h-LC50 of 98.6 was determined for the test substance towards fish as geometric mean of LC0/LC100.
- Executive summary:
A study was performed to assess the acute toxicity of the test substance to Danio rerio under static conditions in accordance with Council Regulation (EC) Method C.1 'Acute toxicity for Fish' (1992).
Groups of ten fishes were exposed to test concentration of 35 to 200 mg/L (nominal concentration) of the test substance. Auxiliaries used to prepare the test media was an ultrasonic bath.During the test a temperature range of 20 - 24°C was be maintained in the test vessels, with a maximum temperature fluctuation of +/- 1°C in each individual test. pH and oxygen values are measured at the beginning of the test and every 24 hours thereafter.
Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 0, 24, 48, 72 and 96 hours of exposure.
The following values were determined after 96 h: LC0 = 49.6 mg/L and LC100 = 195.9 mg/L as arithmetic means of the analytical determined concentrations, the LC50 of 98.6 mg/L was determined as geometric mean of LC0/LC100.
Referenceopen allclose all
Description of key information
A study was performed to assess the acute toxicity of the test substance to Danio rerio under static conditions in accordance with Council Regulation (EC) Method C.1 'Acute toxicity for Fish' (1992).
Groups of ten fishes were exposed to test concentration of 35 to 200 mg/L (nominal concentration) of the test substance. Auxiliaries used to prepare the test media was an ultrasonic bath.During the test a temperature range of 20 - 24°C was be maintained in the test vessels, with a maximum temperature fluctuation of +/- 1°C in each individual test. pH and oxygen values are measured at the beginning of the test and every 24 hours thereafter.
Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 0, 24, 48, 72 and 96 hours of exposure.
The following values were determined after 96 h: LC0 = 49.6 mg/L and LC100 = 195.9 mg/L as arithmetic means of the analytical determined concentrations, the LC50 of 98.6 mg/L was determined as geometric mean of LC0/LC100.
In the definitive test FOE-hydroxy exhibited a 96hr LC50 of 23mg/L (Water Accommodated Fractions (WAFs)) to the marine fish Cyprinodon variegatus in the water phase. This test result is based on measured concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 98.6 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 23 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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