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EC number: 607-997-7 | CAS number: 26776-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-06-26 to 2007-07-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: high concentration of solvent, no substance specific analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- (1984)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Version / remarks:
- (1988)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- The test substance was directly weighed into Erlenmeyer flasks (incubation vessel) and stirred test item for 16 hours before start of incubation time.
- Test organisms (species):
- activated sludge
- Details on inoculum:
- The sludge originated from the aeration tank of a domestic sewage treatment plant (municipal STP Cologne-Stammheim). The sludge was aerated before use and daily fed with synthetic medium. Concentration of the activated sludge: 960 mg/L suspended solids
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2° C
- pH:
- 6.9
- Nominal and measured concentrations:
- nominal: 10, 100 and 1000 mg/L
concentration of reference substance: 5, 10 and 20 mg/L - Reference substance (positive control):
- yes
- Remarks:
- 3.5-Dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- Test concentration Inhibition [%]
10 mg/L 0
100 mg/L 0
1000 mg/L 0 - Results with reference substance (positive control):
- Test concentration Inhibition [%]
5 mg/L 24.2
10 mg/L 55.8
20 mg/L 88.3 - Validity criteria fulfilled:
- yes
- Conclusions:
- The test item showed no toxic effects on microorganisms (0% respiration inhibition) at a concentration of 1000 mg/L, corresponding to 720 mg 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/l. The EC50 of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane is therefore above 720 mg/L.
- Executive summary:
A study was performed to assess the toxicity ofa 72 % solution of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane in 2-methoxy-1-methylethylacetateto bacteria. The study was conducted in accordance with the Commission Directive 88/302/EEC; Official Journal of the EG L133 Part C.11 (1988) and OECD Guideline 209 “Activated Sludge, Respiration Inhibition Test” (1984). The activated sludge was exposed to the test item at concentrations of 10, 100 and 1000 mg/L. The respiration rate of each mixture was determined after an aeration period of 3 hours. The test item showed 0.0 % respiration inhibition of activated sludge at a test item concentration of 1000 mg/L. The EC50 is higher than 1000 mg test item/L, corresponding to 720 mg2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/L. The effect value related to nominal concentration, since no analytical monitoring was performed.
Reference
Description of key information
A study was performed to assess the toxicity of a 72 % solution of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane in 2-methoxy-1-methylethylacetate to bacteria. The study was conducted in accordance with the Commission Directive 88/302/EEC; Official Journal of the EG L133 Part C.11 (1988) and OECD Guideline 209 “Activated Sludge, Respiration Inhibition Test” (1984). The activated sludge was exposed to the test item at concentrations of 10, 100 and 1000 mg/L. The respiration rate of each mixture was determined after an aeration period of 3 hours. The test item showed 0.0 % respiration inhibition of activated sludge at a test item concentration of 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
The EC50 is higher than 1000 mg test item/L, corresponding to 720 mg 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/L. The effect value related to nominal concentration, since no analytical monitoring was performed and the substance is poorly water soluble.
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