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Diss Factsheets
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EC number: 223-445-4 | CAS number: 3896-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988/09/26 to 1988/09/30
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, without analytics.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Non-GLP study, without analytics.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test substance and dispersant were added directly into the tank and homogenously distributed. The fish were then added to the tank.
- Controls: Blank - water; dispersant - 0.67 mg/L alkylphenol polyglycol ether
- Chemical name of dispersant: alkylphenol polyglycol ether
- Concentration of dispersant in test medium (stock solution and final test solution(s) including control(s)): 0.64 mg/L added directly to the water in the tank
- Evidence of undissolved material (e.g. precipitate, surface film, etc): precipitate noted after 24 h - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: West Aquarium/D-3422 Bad Lauterberg, Germany
- Age at study initiation (mean and range, SD): no data
- Length at study initiation (length definition, mean, range and SD): 19-27 mm
- Weight at study initiation (mean and range, SD): 0.05-0.17 g
- Method of breeding: no data
- Feeding during test: no
ACCLIMATION
- Acclimation period: 19 days
- Acclimation conditions (same as test or not):
- Type and amount of food: no data
- Feeding frequency: no food 24 hours prior to exposure
- Health during acclimation (any mortality observed): no data - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 180 mg CaCO3/L
- Test temperature:
- 23+/-1
- pH:
- 8.1-8.3
- Dissolved oxygen:
- 62-103 %
- Nominal and measured concentrations:
- 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Type: open
- Material, size, headspace, fill volume: glass, 20L, fill volume = 15 L
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.08 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 hours/8 hours light/dark
- Light intensity: No data, fluorescent light
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, visible abnormalities, water quality characteristics, were measured daily - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: Swimming behaviour in 2/20 at 100 mg/L
- Observations on body length and weight: no data
- Other biological observations: none
- Mortality of control: none in blank or dispersant controls
- Other adverse effects control: none in blank or dispersant controls
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Precipitation observed after 24 hours
- Effect concentrations exceeding solubility of substance in test medium: yes
Reference
Description of key information
With high probability acutely not harmful to fish. No toxic effects in the range of water solubility.
Key value for chemical safety assessment
Additional information
In a 96-h acute toxicity study, zebra-fish (Brachydanio rerio) were exposed to test item at nominal concentrations of 0 (control, solvent control) and 100 mg/L under static conditions. The 96-h LC50 was > 100 mg/L. The NOEC, based on mortality and sublethal effects, were ≥ 100 mg/L, respectively. Sublethal effects were not observed. It can be concluded that the test substance is not acutely toxic to fish in the range of solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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