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EC number: 216-341-5 | CAS number: 1561-92-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
protocol studies for eye and skin irritation showed slight and very rapidly and totally reversible irritation only . See robust summaries in 7.3.1 and .3.2,
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study from 1981, pre-dating OECD protocols and GLP. Lees weel documented than more recent studies, but sufficient for risk assessment and C&L
- Principles of method if other than guideline:
- animal model: rabbit, 6 male
mode of application: test substance dissolved in water; under occlusion; 2 patches per animal (after shaving , abraded and non-abraded patch.
Observation: 24 and 2 hours after application
Rating - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: H. Fortkamp, 4540 Lengerich.
- Age at study initiation: 11- 17 weeeks
- Weight at study initiation: 2.46-3.02 kg
- Housing: Individual cages, straw bedding Die Versuchstiere wurden einzeln in Stahlkafigen auf Lochblechböden über mit Einstreu gefüllten Kotwannen in klimatisierten Raumen unter konven- tionellen Bedingungen gehalten (10 x Luftwechsel/ Stunde, Raumtemperatur 2 0 - 2 3 °C, relative Luftfeuchtigkeit von 40 - 70 %, 12 Stunden Tag- Nacht-Rhythmus). Einstreu wurde so oft wie für die Hygiene notwendig gewechselt. Die Wasserflaschen wurden wöchentlich gereinigt.
- Diet (e.g. ad libitum): at lib.
- Water (e.g. ad libitum): at lib.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 40-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: Sept To:Oct 1981 (dates not given) - Type of coverage:
- occlusive
- Preparation of test site:
- other: one patch shaved, one patch shaved and abraded
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg, wetted-out with aqua dest.
- Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 72 hrs
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 * 2.5 cm
- % coverage: 100
- Type of wrap if used: self-adhesive plastic foil
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not. residues removed with tissue
- Time after start of exposure: 24
SCORING SYSTEM: Draize: redness 0-4; edema 0-4 - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- ca. 4
- Max. score:
- 48
- Reversibility:
- fully reversible within: 71
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 0
- Max. score:
- 48
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24
- Score:
- ca. 6
- Max. score:
- 48
- Reversibility:
- fully reversible within: 72
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 0
- Max. score:
- 48
- Irritant / corrosive response data:
- 24 hrs: grade 1 redness in 2/6 animals; grade 1 edema in 3/6 animals
72 hrs: no redness or edema remaining - Other effects:
- none
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- slightly irritating but insufficient for classification
- Executive summary:
Sodium methallyl sulphonate, 500 mg humified, was applied to both abraded and intact skin on 6 young male New Zealand White rabbits on patches of 2.5 cm * 2.5 cm. After 24 hrs, the occlusive bandaging was removed, After 24 hrs. minimal to slight redness was observed in 2/6 animals, and minimal to slight edema in 3/6 animals. After 72 hrs no effects were visible. Substance need not be classified for irritative effects
Reference
Animal nr |
Weight |
Time |
Redness |
edema |
||||
abraded |
intact |
abraded |
intact |
|||||
7 |
2.87 |
24 |
1 |
1 |
1 |
1 |
||
72 |
0 |
0 |
0 |
0 |
||||
8 |
2.58 |
24 |
1 |
1 |
1 |
1 |
||
72 |
0 |
0 |
0 |
0 |
||||
9 |
2.46 |
24 |
0 |
0 |
0 |
0 |
||
72 |
0 |
0 |
0 |
0 |
||||
10 |
3.02 |
24 |
0 |
0 |
0 |
0 |
||
72 |
0 |
0 |
0 |
0 |
||||
11 |
2.66 |
24 |
0 |
0 |
0 |
0 |
||
72 |
0 |
0 |
0 |
0 |
||||
12 |
2.88 |
24 |
0 |
0 |
1 |
1 |
||
72 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: old study, predating GLP. performed in accordance with contemporary guideline. sufficient information for C&L
- Qualifier:
- according to guideline
- Guideline:
- other: IRGL Testing Standards 1981
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: H. Fortkamp, Lengerich, DE
- Age at study initiation: 11-17 weeks
- Weight at study initiation: 2,42-2.92 kgs
- Housing: singly in steel cages with straw bedding
- Diet (e.g. ad libitum): at lib
- Water (e.g. ad libitum):at lib
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 40-70
- Air changes (per hr):10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: not specified - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- approx. 0.1 ml= 0.43.6 mg
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 2 hra, 1,2,3,7 and 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- animal as its own control - left eye instilled, right eye untreated
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 2 hours post application
- Score:
- ca. 7.83
- Max. score:
- 110
- Reversibility:
- fully reversible within: 2 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- ca. 1
- Max. score:
- 110
- Reversibility:
- fully reversible within: 1 day
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 2 , 3, 4, 7 days
- Score:
- ca. 0
- Max. score:
- 110
- Reversibility:
- other: fully reversed
- Irritant / corrosive response data:
- 2 hours post application: hyperaemia in all 6 anumals and minor ocular secretion. all animals slicht chemosis, slicht cornea haze in one animal.
afteron day hyperaemia in 3/6 animals;
day 3 and beyond no signs of ocular irritation - Other effects:
- None
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not an eye irritant
- Executive summary:
sodium methallyl sulfonate was tested for eye irritancy in 6 male albino rabbits. after installation if about half a milligram, redness of the coniunctivae was observed in 6 of the animals, and a hazy cornea in one. On dday two , redness was still visible in 3 animals, on day 3 and beyond no signs of eye irritation were observed, The substance is slightly irritating to the eyes, but need not be classified in view of the slight character of the lesions and the rapid and total reversibility.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
protocol study
Justification for selection of eye irritation endpoint:
protocol study
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
protocol studies for eye and skin irritation showed skight and very rapidly and totally reversible irritation only. See robust summaries in 7.3.1 and .3.2,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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