Registration Dossier
Registration Dossier
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EC number: 201-924-9 | CAS number: 89-62-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Database
- Title:
- 2-Nitro-4-metyhylaniline
- Author:
- KEMI Swedish Chemical Agency
- Year:
- 2 011
- Bibliographic source:
- Kemi-Riskline database; Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie Vol:118 (2000) 18 p
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Kemi-Riskline database
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-nitro-p-toluidine
- EC Number:
- 201-924-9
- EC Name:
- 2-nitro-p-toluidine
- Cas Number:
- 89-62-3
- Molecular formula:
- C7H8N2O2
- IUPAC Name:
- 4-methyl-2-nitroaniline
- Details on test material:
- - Name of test material: 2-nitro-p-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.15
- Substance type: organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 903 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: other details not available
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 2-nitro-p-toluidine in rat (Rattus norvegicus) was found to be 1903 mg/kg of body weight. Acute toxicity of 2-nitro-p-toluidine to rat by the oral route indicates that the substance exhibits acute toxicity category IV by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of 2-nitro-p-toluidine in rat was found to be 1903 mg/kg of body weight. Acute toxicity of 2-nitro-p-toluidine to rat by the oral route indicates that the substance exhibits acute toxicity category IV by the oral route.
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