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Diss Factsheets
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EC number: 278-934-5 | CAS number: 78521-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- pH 4: (Citrate buffer acc. to Sörensen):
- Composition of buffer: Citric Acid, NaOH, HCl, destilled water
pH 7: (Phosphate buffer acc. to Sörensen):
- Composition of buffer: K2PO4-Solution, Na2HPO4-Solution
pH 9: (Borate buffer acc. to Sörensen):
- 85 mL of Borax solution (1.91 g Borax ad 100 mL Water) plus 0.1 N HCl and 1 N NaOH to adjust pH to 9.006 - Details on test conditions:
- - 1 g test item plus 10 mL solution of pH 4, 7, 9 respectively.
- pH measurement at t=0 and t=5d.
- stirring for 5 d at 50 °C.
pH 9 solution: the pH was too low after test item addition. Therefore, the amount of test item was lowered: 0.1 g plus 15 mL pH 9 buffer solution. - Duration:
- 5 d
- Temp.:
- 50 °C
- Number of replicates:
- 1
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- Details on results:
- pH 4: pH value at t0 = 3.5 - 4; at t5d = 4.016
- residue after filtration: no degradation detectable
- filtrate: ASC plus detectable, about 1 % of the total quantity of ASC plus found, total amount of all detected peaks except ASC plus in the filtrate = 0.5 % of original test substance concentration in the buffer solution pH 4
pH 7: pH value at t0 = 6-6.5; at t5d = 5.767
- residue after filtration: no degradation detectable
- filtrate: about 8.7 % ASC plus of the total quantity of original test substance found, total amount of all peaks except that of ASC plus = 0.28 % of original test substance concentration in the buffer solution pH 7.
pH 9: pH value at t0 = 9; at t5d = 8.672
- residue after filtration: no residue available, substance has fully dissolved
- filtrate: mainly ASC plus was found with no significant degredation. - Validity criteria fulfilled:
- yes
- Executive summary:
ASC plus (6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid) was stable against hydrolysis at pH 4, pH 7 and pH 9 (5d at 50 °C) in a test according to OECD 111.
Reference
stable against hydrolysis at pH 4, pH 7 and pH 9 (5d at 50 °C)
Description of key information
ASC plus (6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid) was stable at pH 4, pH 7 and pH 9 (5d at 50 °C) in a test according to OECD 111.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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