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EC number: 225-590-9
CAS number: 4948-15-6
Results of analytical measurements:
Particle size analysis:
The MMAD 50% = 3.0 µm (geometrical standard deviation =3.6) was
calculated from the results of the particle size analysis.
A respirable dust aerosol fraction that might reach the alveolar region
of 82% was obtained from the results of the particle size analysis.
In an inhalation toxicity study according to OECD guideline 403, Wistar rats (5/sex) were exposed to the test article as dust for 4 hours at a measured concentration of 5.2 mg/L followed by a 14-day observation period. Cascade impactor measurements resulted in a particle size distribution with a mass median aerodynamic diameter (MMAD) of 3 µm (GSD: 3.6), which is well within the respirable range. None of the animals died during the study period. Clinical signs included irregular, accelerated and/or intermittent respiration, flight behaviour and discoloured fur. From day 7 of the observation period onward, no abnormalities, except discoloured fur, were detected in the animals. The body weight gain of male and female rats in the test group, compared with a historical control collective, was not affected by the substance over the total observation period. No pathologic findings were noted during gross pathology. The LC50 determined on the basis of the study results was >5.2 mg/L.
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