Registration Dossier
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EC number: 202-707-1 | CAS number: 98-85-1
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical 1-phenylethan-1-ol (CAS no. 98-85-1) (HSDB and PubChem, 2017). The bioaccumulation factor (BCF) value was calculated using a measured water solubility of 1950 mg/l at 25°C and a regression-derived equation. The estimated BCF (bioaccumulation factor) valueof1-phenylethan-1-ol was determined to be 9 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 1-phenylethan-1-olis considered to be non-accumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic / sediment
Experimental study and various predicted data for the target compound 1-phenylethan-1-ol (CAS No. 98-85-1) were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative databases (HSDB and PubChem, 2017), bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical 1-phenylethan-1-ol (CAS no. 98-85-1). The bioaccumulation factor (BCF) value was calculated using a measured water solubility of 1950 mg/l at 25°C and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of 1-phenylethan-1-ol was determined to be 9 dimensionless.
In aprediction done using theBCFBAF Programof Estimation Programs Interface (from peer reviewed journal A.M. Api et. al., 2017 and modelling databases, 2018) was used to predict the bioconcentration factor (BCF) of test chemical 1-phenylethan-1-ol (CAS no. 98-85-1).The bioconcentration factor (BCF) of 1-phenylethan-1-ol was estimated to be 2.23 L/kg whole body w.w (at 25 deg C).
Using Bio-concentration Factor module (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)), Bio-concentration Factor of the test substance 1-phenylethan-1-ol (CAS no. 98 -85 -1) was estimated to be 6.61, 6.59, 6.37 and 4.81 dimensionless at pH range 1-11, 12, 13 and 14, respectively.
On the basis of above results for target chemical 1-phenylethan-1-ol (from peer reviewed journal, authoritative databases HSDB, Pubchem, EPI suite and ACD lab database,2017), it can be concluded that the BCF value of test substance 1-phenylethan-1-ol ranges from 2.23 – 9 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 1-phenylethan-1-olis not expected to bioaccumulate in the food chain.
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