N-ethylpropylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

A test group consisting of 5 animals/sex was treated by single dermal application of the test substance. No more than 16 hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. On the testing day, the dermal applications (200 mg/kg bw) of the test material were made in undiluted form on the exposure sites (ca. 50 cm²) of the rabbits. After application, the exposure site was covered by wrapping the trunk of the animal with an parchment paper which was securely taped in place. The test material remained in contact with the skin for 24 hours. Observations for mortality, local reactions, and behavioral abnormalities were continued for a total of 5 days following the skin applications.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N-ethylpropylamine

EC Number:

243-573-4

EC Name:

N-ethylpropylamine

Cas Number:

20193-20-8

Molecular formula:

C5H13N

IUPAC Name:

N-ethylpropan-1-amine

Details on test material:

- Name of test material (as cited in study report): Aethylpropylamin
- Physical state: liquid
- Analytical purity: 99 %

Test animals

Species:

rabbit

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2-3 kg
- Housing: individually
- Diet: Standard-pellet feed for rabbits ad libitum
- Water: tap water ad libitum
- Acclimation period: > 7 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 7 x 7 cm = ca. 50 cm²
- Type of wrap if used: The exposure site was covered by wrapping the trunk of the animal with a parchment paper which was securely taped in place (Gazofix, No. 2938, Beiersdorf)

Duration of exposure:

24 h

Doses:

200 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 5 days
- Frequency of observations: 1 h, 24 h, 48 h, 72 h
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality observed. Exposed area was leathery, coarse, dry and heavy scabbed with a dark red to black colour (5 days post-application).

Mortality:

No mortality occurred.

Clinical signs:

other: 5 days post application the exposed area is leathery, coarse, dry and heavy scabbed with a dark red to black colour.

Gross pathology:

not performed

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