Registration Dossier
Registration Dossier
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EC number: 298-790-7 | CAS number: 93839-20-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-[4-(aminocarbonyl)phenyl]-4-methoxy-3-nitrobenzamide
- EC Number:
- 298-790-7
- EC Name:
- N-[4-(aminocarbonyl)phenyl]-4-methoxy-3-nitrobenzamide
- Cas Number:
- 93839-20-4
- Molecular formula:
- C15H13N3O5
- IUPAC Name:
- N-(4-carbamoylphenyl)-4-methoxy-3-nitrobenzamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hoe: WISKf(SPF71)
- Source: Hoechst AG, company breeding colony
- Age at study initiation: males about 7 weeks; females about 8 weeks
- Mean weight at study initiation: males: 194+-2 g; femals: 171+-5 g
- Fasting period before study: 16 hours
- Housing: in macrolon cages in completely air conditioned rooms; 5 animals per cage
- Diet: Altromin 1324 ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3
- Humidity (%): 50+-20
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2% starch mucilage
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 mals and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: twice a day and weighing: once a week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: males and females showed squatting posture and irregular respiration. These symptomes disappeared 2 days after dosing
- Gross pathology:
- no effects
- Other findings:
- no otherf findings
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50: > 2000 mg/ kg bw
- Executive summary:
The substance was tested for acute oral toxicity in the Wistar rat (5 mals and 5 females) according to OECD 401 (limit test) using a dose of 2000 mg/kg bw. No lethality occured, but irregular respiration and squatting posture was observed. These symptoms disappeared 2 days after dosing. The development of the body weight was normal. Necropsy revealed no abnormal findings. LD50 was above 2000 mg/ kg bw.
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