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EC number: 212-572-0 | CAS number: 827-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Four studies are available that assess the biodegradation of cyclohexylbenzene.
In the first study (Gagel, 1983), the biodegradation of cyclohexylbenzene is assessed via a River Die Away test. In this test, water from the Mississippi River is spiked with 50 ppb of cyclohexylbenzene. The decrease in concentration of cyclohexylbenzene in the test vessels was examined after 1, 3, 7, 14 and 28 days by GC FID analysis. The experiment demonstrated that the parent chemical disappeared from the test solution within 14 days. The half-life determined for cyclohexylbenzene is in the order of 6-8 days. Therefore, the study concludes that cyclohexylbenzene is readily biodegradable in Mississippi river water.
Two studies (Heim, 2001; and Saeger and Kuehnel, 1983) evaluate the ultimate biodegradation of cyclohexylbenzene by monitoring the CO2 evolution from the biometric flasks.
In the study by Heim, the test substance is exposed activated sludge from a wastewater treatment plant that receives predominantly domestic sewage at a test substance concentration of 20 mg carbon/L for 29 days. Sampling was performed on days 3, 6, 8, 10, 15, 20, 24 and 29. The percent theoretical (% ThCO2) for the test substance system was 14.3% and 1.3% for replicates 1 and 2, respectively, by day 29 of the study.
In the study by Saeger and Kuehnel, 20 mg/L of cyclohexylbenzene was exposed over a 55 -day period to a commercially available inoculum purported to be specifically adapted to hydrocarbons. The cyclohexylbenzene yielded a mean CO2 evolution of 12 percent.
Finally, a semi-continuous activated sludge (SCAS) test (Saeger and Tucker, 1973) was performed MCS 1567 on a mixture containing 70% cyclohexylbenzene and 30% biphenyl. The disappearance rates of the 2 constituents was determined via UV spectroscopic analysis on concentrated extracts from the samples. The activated sludge was pre-exposed to the test substance for 2 weeks prior to the determination of the degradation rate. Under the conditions of the SCAS test, the substance undergoes rapid primary degradation. Volatility losses were not a significant factor in the disappearance rate. The efficiency of the applied extraction protocol was confirmed via spiking experiments, thus indicating that the removal of the test compound was not related to mere adsorption to the sludge.
Overall, the available experimental data indicate that cyclohexylbenzene is inherently biodegradable and undergoes at least primary degradation, as demonstrated by the loss of parent chemical in the River Die Away test. The half-life for primary degradation is in the range of 6-8 days. Ultimate degradation occurs more slowly, with a degradation up to ca. 14% after 29 days, depending on the inoculum and test conditions.
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