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Diss Factsheets
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EC number: 203-057-1 | CAS number: 102-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- mechanistic studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Cholinesterase inhibition in the acute toxicity of alkyl-substituted 2-Aminoethanols
- Author:
- Hartung R, Cornish HH
- Year:
- 1 968
- Bibliographic source:
- Toxicology and applied pharmacology, 12: 486-494
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute oral and intraperitoneal toxicity of a series of alkyl-substituted 2-aminoethanols was studied in relation to cholinesterase inhibition. The oral and intraperitoneal toxicities of these compounds were studied in male Sprague-Dawley rats. Cholinesterase inhibition was conducted in vitro, using a purified enzyme preparation derived from bovine erythrocytes. In vivo cholinesterase inhibition was also investigated in brain and red cells of treated animals.
- GLP compliance:
- no
- Type of method:
- other: in vitro and in vivo
- Endpoint addressed:
- neurotoxicity
Test material
- Reference substance name:
- 2-dibutylaminoethanol
- EC Number:
- 203-057-1
- EC Name:
- 2-dibutylaminoethanol
- Cas Number:
- 102-81-8
- Molecular formula:
- C10H23NO
- IUPAC Name:
- 2-(dibutylamino)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dibutylaminoethanol
No further data available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intraperitoneal and oral
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
- Details on results:
- The data of this publication indicate that neutralized N-alkyl substituted 2-aminoethanols inhibit cholinesterase in vitro. Inhibition increases as the degree of substitiution and the molecular size of the nitrogenous head of the aminoethanol molecule increase.
The oral LD50 values are uniformly higher than the intraperitoneal LD50 values (Dibutylaminoethanol: oral LD50: 1.78 g/kg bw (1.33 - 2.39); intraperitoneal LD50: 0.144 g/kg bw (0.091 - 0.219).
When the toxicity data and the inhibitory concentrations (50% inhibition) are compared on the basis of molar concentrations, some interesting trends become evident. As the inhibitory capacity of the substituted 2-aminoethanol increases, there appears to be a concurrent increase in the intraperitoneal toxicity, resulting in a very significant correlation coefficient of r = 0.676. When the oral LD50 values are compared on the same basis, they generate a correlation coefficient of r = 0.378, which has only marginal significance. For Dibutylaminoethanol an inhibitor concentration producing 50% inhibition of 1.1 mmol/Liter was found and correlated to an oral LD50 of 10.3 and and i.p. LD50 of 0.831 mmol/kg.
When four of the aminoethanols (Ethylaminoethanol, Dimethylaminoethanol, Dibutylaminoethanol, Dibutylcholine) were given intraperitoneally, they produced moderate but significant depressions in brain cholinesterase activities. A significant depression in red cell cholinesterase activity was only noted for Dimethylaminoethanol.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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