A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD TG 403

Deviations:

yes

Remarks:

: Exposure duration: 7 hours

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate

EC Number:

415-430-8

EC Name:

A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate

Cas Number:

86403-32-9

Molecular formula:

C25H49NO2 and C27H53NO2

IUPAC Name:

Reaction mass of 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate and 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

7 hour exposure, whole body
14-day observation period

Analytical verification of test atmosphere concentrations:

yes

Remarks:

23.1 mg in total volume of 4.63 m3 of air

Duration of exposure:

7 h

Concentrations:

5 mg/m3.

No. of animals per sex per dose:

5 males and 5 females per control group; 5 males and 5 females per treatment group

Control animals:

yes

Details on study design:

the air passed through the test substance and enriched itself by means of the volatilisation or sublimation of the test substance .
This ensured an Inhalation of the maximum attainalble concentration to estimate the hazard limits safety.

Statistics:

not performed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

5 mg/m³ air

Based on:

test mat.

Remarks:

max. attainable vapour concentration

Exp. duration:

7 h

Remarks on result:

other: No deaths occurred at this concentration. LC50 > 5 mg/m3

Mortality:

None

Clinical signs:

other: All animals were normal in appearance and behavior.

Body weight:

All animals gained weight during the study

Other findings:

In all animals, organs and cavities were of normal appearance. Decreased somatomotor activity was observed in both control and treatment groups. This was attributed to increased temperature within the exposure chamber.
LC50: >5mg/m3

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The substance was tested in an OECD-compliant acute inhalation toxicity test in rats with an exposure duration of 7 hours. No deaths occurred at the highest dose tested, so the LC50 is > 5 mg/m3 (> 0.005 mg/l).