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Diss Factsheets
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EC number: 221-660-8 | CAS number: 3179-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 600 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A well-reported, repeated dose 90-day oral toxicity study on 3-aminopropyltriethoxysilane (CAS 919-30-2), conducted in the main according to the current guideline for that endpoint and in accordance with GLP, identified a systemic NOAEL value of 200 mg/kg bw/day in male and female rats; mortality, clinical observations and liver effects were evident at 600 mg/kg bw/day (WIL, 2001). No effects on reproductive organs, oestrus cycle or sperm parameters were evident at the highest tested dose of 600 mg/kg bw/day.
Although it is accepted that this study cannot detect all possible reproductive effects, the 90 day oral toxicity study is considered adequate to cover testing requirements for reproductive toxicity as laid out in Annex IX.
Read-across from 3-aminopropyltriethoxysilane to 3-(diethoxymethylsilyl)propylamine is discussed in Section 7.5.
Short description of key information:
A reliable 90-day oral toxicity study in rats (WIL, 2001) on the related 3-aminopropyltriethoxysilane (CAS 919-30-2), which may be used as a read-across study, reported a NOAEL for reproductive effects of 600 mg/kg bw. This study would have only limited potential to detect all possible reproductive effects.
Justification for selection of Effect on fertility via oral route:
The selected study is the only available reproductive toxicity study for a relevant surrogate substance. It was conducted in accordance with a protocol similar to OECD 418 and in compliance with GLP.
Effects on developmental toxicity
Description of key information
A study in rats (Momentive, 1998) on the related 3-aminopropyltriethoxysilane (CAS 919-30-2), which is used as a read-across study, reported a maternal and developmental NOAEL of 100 mg/kg bw. However, the author of this CSR considers that the NOAEL relevant for human hazard assessment was 600 mg/kg bw/day, the highest dose tested.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 600 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A well reported oral study in rats, conducted according to generally accepted scientific standards (similar to OECD 414) and in accordance with GLP reported maternal toxicity (increased incidences of mortality, clinical observations, and slight decreases in body weight gain and food consumption) at 600 mg/kg bw/day (Momentive, 1998). The occurrence of maternal toxicity was accompanied by slight fetal toxicity (increased minor skeletal variations). No significant maternal or developmental effects were observed at 20 or 100 mg/kg bw/day. However, the increased minor skeletal variation can result from maternal stress and is considered to be minor, and not a threat to normal functioning of the animals, and therefore not of significance for humans. The NOAEL for developmental toxicity (including teratogenicity) was therefore ≥600 mg/kg bw/day.
Read-across from 3-aminopropyltriethoxysilane to 3-(diethoxymethylsilyl)propylamine is discussed in Section 7.5.
Justification for selection of Effect on developmental toxicity: via oral route:
The selected study is the only available developmental toxicity study for a relevant surrogate substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available information on the registered substance and limited read-across data, no classification is proposed for effects on reproduction and development in accordance with Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.