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Diss Factsheets
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EC number: 202-681-1 | CAS number: 98-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not skin irritant
Not eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The test item was applied to the skin of the flank of 6 rabbits, through occlusive coverage. The right flank was treated with the undiluted product, while the left flank was treated with the 10% dilution of the product in sesame oil. The exposure time was 24 hours; the observation period was up to 72 hs. The irritation index was calculated based on erythema and oedema scores after 24 and 72 hours and it was found to be 1.9 for the undiluted product and 0.4 for the dilution.
Eye irritation/corrosion
The test item was instilled into the right eye of 6 rabbits, while the left eye served as control. 0.1 mL of undiluted product was instilled in the eye and washed after 72 hs. The observation period was up to 72 hs. Fluorescein was instilled after 48 hours and 72 hours to assess the scores. The irritation index was calculated based on effects on cornea, iris and conjunctiva after 1, 7, 24, 48 and 72 hours. The maximum score was 2 and it was observed after 7 hours. The effect was fully reversible after 24 hours.
Justification for classification or non-classification
No effects on the eyes after topic application of PCBTF in rabbits were seen. The scores assigned for iris, conjunctiva and cornea were 0. For this reason the test substance is not classified as irritant to the eye according to the CLP Regulation 1272/2008.
As per skin irritation, scores for oedema were not fully reversible after 72 hours. However, considering the very short observation period after application of the substance and the trend of the scores assigned after 24, 48 and 72 hours it is expected fully reversibility within a hypothetical 14 days obsarvation period.
In addition the substance shows no toxicity on the eyes, considered as a higher sensitive organ respect to the skin.
Overall, the test substance is considered to have no irritation potential for the skin and for this reason it is not classified as skin irritant according to the CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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