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Diss Factsheets
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EC number: 252-575-4 | CAS number: 35453-19-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: We extrapolated the results with the read-across approach about eye irritation of Iodoftaluro in the rabbit. Iodoftaluro (5-amino-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride) is a compound of Iodoftal and two molecules of chlorine.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 37441-29-5
- EC Number:
- 609-431-4
- Cas Number:
- 37441-29-5
- IUPAC Name:
- 37441-29-5
- Details on test material:
- The test substance is Iodoftaluro (5-amino-2,4,6-triiodo-1,3-benzene-dicarbonyl dichloride).
CAS number: 37441-29-5
Physical state: powder
pH (10% in water): 2,9
Test substances were stored at room temperature in the dark in a closed cabinet.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino rabbit
- Details on test animals or tissues and environmental conditions:
- 3 males were used
Test system
- Vehicle:
- water
- Controls:
- other: the right eye of each animal was used as control
- Amount / concentration applied:
- A volume of about 0,1 ml with a maximum weight of 100 mg was used.
- Duration of treatment / exposure:
- The test substance was placed in the fornix conjunctivae of the left eye of the rabbit then the eyelids were maintained closed for one second to avoid a loss of substance.
- Observation period (in vivo):
- Animals were examined for signs of eye irritation and the response scored at 1 hour, 24 hours, 48 hours and 72 hours after application according to the grades given in the OECD guideline.
- Number of animals or in vitro replicates:
- There was one rabbit per product for the first run, then two complementary rabbits when the test substance was not found to be irritative.
- Details on study design:
- The eyes were not rinsed during the 24 hours following the application of the test substance. When necessary a rinse was made at the 24th hour.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- animal: #1,2 and 3
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- < 0.3
- Max. score:
- 0.06
- Reversibility:
- fully reversible
- Remarks on result:
- other: 0.06 is the average score
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test substance is not irritative for the rabbit eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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