D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, 2,3,4,6-tetraacetate, (1S)-

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted between 18 June 2014 and 22 August 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Atm. press.:

102.5 kPa

Decomposition:

yes

Decomp. temp.:

250 °C

Thermal Data

Thermographic data for determinations 1 and 2 are shown in the following table.

Thermal Event	Interpretation	Temperature
		Determination 1		Determination 2
		°C	K	°C	K
Endotherm	Melting	131.9	405	131.7	404.8

Visual Assessment by Metal Block

The temperatures and observations recorded during the metal block assessment are shown in the following table.

Time (mm:ss)	Temperature		Observations
	°C	K
00:00	20	293	Test item is a white powder
12:30	131	404	Test item begins to melt
13:00	135	408	Test item has melted into a clear colorless liquid
17:30	160	433	Bubbles forming in the test item
29:00	250	523	Test item is a light brown liquid
32:30	275	548	Test item is a brown liquid
40:00	335	608	Test item is a dark brown liquid
42:50	340	613	Test item is a dark brown/black liquid
44:20	350	623	Test item is a dark brown/black liquid

Discussion

The endotherm observed for the melting temperature gave an onset of approximately 1 °C higher than that determined in Section 3.1. This has been attributed to a measurement lag due to the higher heating rate used in the boiling temperature determination. Due to the low enthalpy change during decomposition it was not possible to determine the exact temperature at which decomposition began. The onset of decomposition has been taken from 250 °C, the temperature where a color change was first noted in the visual assessment.

Conclusions:

The test item has been determined to decompose from 250 °C (523 K). As the test item decomposed, no value for boiling temperature could be determined.

Executive summary:

The general physico-chemical properties of BMS-587172-01 have been determined. The results are summarized below:

Boiling Temperature

Decomposed from 250 °C (523 K) using a metal block method, designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The test item has been determined to decompose from 250 °C (523 K). As the test item decomposed, no value for boiling temperature could be determined.

Description of key information

As the test item decomposed, no value for boiling temperature could be determined.

The test item has been determined to decompose from 250 °C (523 K).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

250 °C

Additional information

Decomposed from 250 °C (523 K) using a metal block method, designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.