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Diss Factsheets
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EC number: 222-023-7 | CAS number: 3320-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Control studies are performed under GLP-conditions but without assignment to a particular study. This allows use of control data for several studies that have been performed under similar experimental conditions within a recent time frame. This procedure is in compliance with current testing guidelines as well as animal welfare regulations.
- GLP compliance:
- yes
- Test type:
- other: acute inhalation toxicity test in rats
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorophenyl isocyanate
- EC Number:
- 222-023-7
- EC Name:
- 2-chlorophenyl isocyanate
- Cas Number:
- 3320-83-0
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-2-isocyanatobenzene
- Details on test material:
- Purity: 99.7 %,
Molecular weight: 153.5 g/mol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Remarks on duration:
- nose-only conditions
- Concentrations:
- 32, 47, 63, 125, and 184 mg/m³ air.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 47 mg/m³ air
- Exp. duration:
- 4 h
Any other information on results incl. tables
Results:
LC50 inhalation (vapour, 4 hr | NO(A)EL |
Males and females combined ca. 47 mg/m³ air* | Males and females: <32 mg/m³ air* |
* All concentration data represent actual concentrations of the test substance in the rats breathing zone.
Observations and measurements:
Exposure to vapour concentration of 32 mg/m³ did not induce test substance related mortality. Exposure to 47 mg/m³ air and above was followed by a characteristic type of mortality pattern occurring within post exposure days 1 through 18. Marked gender specific differences in susceptibility was not observed. Exposures to concentrations of 32 mg/m³ and above were followed by a concentration-dependent signs indicative of or secondary to respiratory tract irritation, such as bradypnea, dyspnea, labored breathing pattern, rales, nostrils with red encrustrations, cyanosis, prostration (lying on side and belly), reduced motility, ungroomed hair coat, hypothermia, decreased body weights and piloerection. The duration of signs (maximum duration up to day 28), in most instances, was dependent on respiratory signs. Gross necropsy (among others) revealed less collapsed, consolidated, discolorated (dark-red) lungs with serous mucus in the airways, including trachea. The lung associated lymph nodes were enlarged. Clinical observations and necropsy findings support the conclusion that a causal relationship between lethality and lung damage existed.
Applicant's summary and conclusion
- Executive summary:
A study on the acute inhalation toxicity of the test substance in male and female Wistar rats has been conducted in accordance with OECD Guideline No. 403. Groups of rats were nose-only exposed for four hours to average vapour concentrations of 32, 47, 63, 125, and 184 mg/m³ air.
The LC50 for males and females combined was found to be ca. 47 mg/m³ air.
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