Registration Dossier
Registration Dossier
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EC number: 213-268-0 | CAS number: 933-48-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data, list III.
- Author:
- Smyth HF Jr, Carpenter CP and Weil CS . J. Ind. Hyg. Toxicol. 31, 60-62.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 60-62.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
Test material
- Reference substance name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 213-268-0
- EC Name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 933-48-2
- Molecular formula:
- C9H18O
- IUPAC Name:
- (1R,5R)-3,3,5-trimethylcyclohexan-1-ol
- Details on test material:
- Test substance: other TS: 3,3,5-Trimethylcyclohexanol, no further data, no further information about the isomeric ratio
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino (not specified)
Test system
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Number of animals or in vitro replicates:
- 5
- Details on study design:
- Comment: not rinsed
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 h
- Score:
- 9
- Max. score:
- 20
Any other information on results incl. tables
Grade 9
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- The eye irritation was rated 9 out of 20 points in a study with albino rabbits. A score of >5 was indicated as severe injury
- Executive summary:
A eye irritating study was conducted with albino rabbits. The eye irritation was rated 9 out of 20 points. A score of >5 was indicated as severe injury. Hence under the conditions of this study the substance is considered to be irritating to eyes.
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