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Diss Factsheets
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EC number: 455-560-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- At the start of the final test, duplicate samples were taken from the vessel used for the fish test. Done to determine if the solution was homogenous. The study integrity was not adversely affected by the deviation.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Clear colourless liquid, purity 96.5%.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- A stock solution of 100 pentamethyl-trioxepane was prepared in M7 medium after 15 min. of magnetic stirring.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- In house laboratory culture with a known history. Each batch was started with daphnids < 3days old. 250 daphnids in 5L M7 medium in a glass vessel. Max. age 4 weeks. Medium temp. 18-22 °C. Feed: daily, suspension of fresh water algae
Age at study initiation: < 24 hours - Test type:
- static
- Water media type:
- other: M7 medium
- Remarks:
- Tap water purified by reverse osmosis, milli-RO, from which ISO medium is prepared.; M7 medium is prepared with the ISO medium.
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/l pH: 8.0 ± 0.2 after aeration
- Test temperature:
- 19.3 - 20.2 °C
- pH:
- 7.9-8.0
- Dissolved oxygen:
- 9.3
- Nominal and measured concentrations:
- Nominal concentrations:
Range-finding test: blank-control, 0.1, 1, 10 and 100 mg/l. final test: 100 mg/l
Measured concentrations:
Final test: T=0 not detected in control and 75.8 and 72.2 in the samples. T=48 not detected in control and 60.3 in sample and 48.6 in reserve sample. At the end of the test the conc. declined > 80% therefore further calculations were performed with the measured conc. - Details on test conditions:
- see Any other information on materials and methods incl. tables
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 63 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: no daphnia became immobilized at any test conc.
- Remarks on result:
- other: also 24 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 63 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: no daphnia became immobilized at any test conc.
- Remarks on result:
- other: also 24 h
- Details on results:
- Range-finding test and final test: no daphnia became immobilized at any of the test concentrations.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study pentamethyl-trioxepane did not induce acute immobilization of Daphnia magna at 63 mg/l after 48 hours of exposure (NOEC). 24 & 48h-EC50 >63 mg/l.
- Executive summary:
24 & 48h-EC50>63 mg/l.
Reference
The value of pentamethyl-trioxepane in solution measured at the end (48h) of the test in the sample and the reserve varies 60.3 mg/ml and 48.3 mg/ml. This variation may result from variability in the analytical method. Therefore the mean of these values is used for further calculations. The average exposure concentration was calculated to be 63 mg/l.
Control group: 20 daphnia, 5 per 80 ml test medium without the test substance or other additives vessel in quadruplicate.
Description of key information
Under the conditions of the present study pentamethyl-trioxepane did not induce acute immobilization of Daphnia magna at 63 mg/l after 48 hours of exposure (NOEC). 24 & 48h-EC50 >63 mg/l.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.