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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 474-470-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive CE - Méthode B.1 tris et OCDE 423.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test animals
- Species:
- other: Rat, Sprague-Dawley
Administration / exposure
- Vehicle:
- other: Solution aqueuse de méthylcellulose à 0,5 %.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 300 mg/kg bw
- Mortality:
- Female: 300 mg/kg bw; Number of animals: 6; Number of deaths: 3
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 50 mg/kg bw; Number of animals: 6; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
A la dose de 300 mg/kg, 3 animaux sont morts dans les
24 heures qui suivent le traitement. De l'hypoactivité ou de
la sédation, de la dyspnée, de la piloérection et un
décubitus latéral sont les signes cliniques qui ont précédé
la mort des animaux.
Hypoactivité, piloérection et dyspnée (1/3 animal survivant)
sont les signes cliniques observés chez les animaux
survivants dans les 5 heures qui ont suivi le traitement.
Plus aucun signe clinique n'est noté à partir du Jour 2,
jusqu'au terme de l'étude.
A la dose de 2000 mg/kg, tous les animaux sont morts dans
les 45 minutes qui suivent le traitement. Aucun signe
clinique n'est enregistré avant la mort des animaux.
A la dose de 50 mg/kg, aucune mortalité et aucun signe
clinique ne sont observés pendant l'étude.
En comparaison avec les valeurs des animaux témoins
historiques, un léger ralentissement du gain de poids
corporel est noté durant la première semaine de la période
d'observation, chez 1/6 femelle traitée à la dose de
300 mg/kg, sans conséquence notable à la fin de l'étude.
L'évolution pondérale globale des autres animaux traités aux
doses de 50 et 300 mg/kg n'est pas affectée par le
traitement avec la substance. - Gross pathology:
- Effects on organs:
Aucune anomalie apparente n'est observée à l'examen
macroscopique des principaux organes des animaux morts en
cours d'étude ou sacrifiés en fin d'étude.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.