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EC number: 236-211-1 | CAS number: 13236-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other:
Test material
- Reference substance name:
- 1,2,3-tris(2,3-epoxypropoxy)propane
- EC Number:
- 236-211-1
- EC Name:
- 1,2,3-tris(2,3-epoxypropoxy)propane
- Cas Number:
- 13236-02-7
- Molecular formula:
- C12H20O6
- IUPAC Name:
- 1,2,3-tris(2,3-epoxypropoxy)propane
- Reference substance name:
- N/A
- Cas Number:
- 178667-42-0
- Molecular formula:
- C12H24O8
- IUPAC Name:
- N/A
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- During the test period, the temperature and humidity of the animal room were recorded by measure data in every 1 hr with an automatic temperature and humidity meter in every 5 min intervals.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test substance was orally administered once.
- Doses:
- 10 mL/kg Body weight
- No. of animals per sex per dose:
- 1st step(300 mg/kg bw): 3/female
2nd step(300 mg/kg bw): 3/female
3rd step(2,000 mg/kg bw): 3/female - Control animals:
- no
- Details on study design:
- 1. Room No.: Rodent 4
2. Cage type and size: Stainless wire cage (420 W×270 L×180 H mm)
3. Animals per cage: 3 animal/cage (during the study)
4. Temperature: 21.0 ~ 23.5 ºC
5. Relative humidity: 45.5 ~ 57.7%
6. Air exchange: 10 ~ 15 / hr
7. Light cycle: 12 hour light / 12 hour dark
8. Illumination: 150 ~ 300 lux
9. Water: Public tap water was filtered and irradiated by ultraviolet light and with ad libitum bottle using automatic feed water system. The absence of contamination was confirmed with periodical analysis results report of manufacture.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals died in the test substance administration group at 2000 mg/kg body weight (3 rd step) respectively. No dead animals were observed in the remaining 300 mg/kg body weight (1 st step and 2 nd step) test substance administration group.
- Clinical signs:
- other: Prone position was observed for all animals 30 minutes after administration in 2000 mg / kg administration group (3 rd step). At 1 hour after administration, Prone position, Soiled perineal region and Soft stool were observed in all animals, one died, the
- Gross pathology:
- In necropsy finding of died animals, Soiled perineal region were observed in all died animals. There were no necropsy findings caused by administration of test substance in all survived animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the result of the acute oral toxicity study in Sprague-Dawley rats, the test substance was classified into GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures) Category 4 in this study.
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