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EC number: 233-822-5 | CAS number: 10377-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 22 June 2022 to 27 July 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Test item and reference item analysis certificates. A deviation was written for the storage of reference item. There is no impact on the study and on the acquired data. The data generated are scientifically acceptable and valid.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium iodide
- EC Number:
- 233-822-5
- EC Name:
- Lithium iodide
- Cas Number:
- 10377-51-2
- Molecular formula:
- ILi
- IUPAC Name:
- lithium iodide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Batch number 1280322A-0915P
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- Analytical method validation of lithium iodide anhydrous in UP water, algae medium and ISO 6341 medium
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test solutions will be prepared by dilution in test medium of a primary stock solution.
The test solutions concentrations will be expressed in concentrations of test item and the endpoints will be calculated with measured concentrations.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Strauss
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19.8 to 24.7
- pH:
- 7.6 - 7 9
- Dissolved oxygen:
- 0 H = 8.0 - 8.2
48H = 7.7 - 8.3 - Nominal and measured concentrations:
- C07 = 0 mg/ L test item
C08 = 0.0625 mg/ L test item
C09= 0.125 mg/ L test item
C10 = 0.250 mg/ L test item
C11 = 0.500 mg/ L test item
C12 = 1 mg/ L test item - Details on test conditions:
- Based on the results of the non-GLP range-finder the test solutions were prepared in
ISO medium at the definitive theoretical concentrations.
A control was set up with the test medium only. There were 4 replicates for each treatment and for the
control. 5 daphnids were introduced in each replicate (each one containing 50 mL of test solution).
Organisms were maintained at temperature in the range of 18°C to 22°C and light intensity under 300
lux (according OECD 202) with a light:dark cycle of 16 hours light and 8 hours dark.
Daphnids were not fed during the test. The test vessels must not be aerated during the test. The test
will be carried out without adjustment of pH.
After 24 and 48 hours, the number of immobile daphnids in each replicate and abnormal appearance
and behaviour were recorded.
pH and dissolved oxygen were recorded at the beginning and the end of the test. - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.42 mg/L
- 95% CI:
- >= 0.38 - <= 0.46
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 to survival and reproduction of Daphnia magna were investigated under laboratory conditions.
- Basis for effect:
- mortality
- Remarks:
- The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 to survival and reproduction of Daphnia magna were investigated under laboratory conditions.
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.67 mg/L
- 95% CI:
- >= 0.58 - <= 0.76
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 to survival and reproduction of Daphnia magna were investigated under laboratory conditions.
- Basis for effect:
- mortality
- Remarks:
- The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 to survival and reproduction of Daphnia magna were investigated under laboratory conditions.
- Details on results:
- The aim of this study was to assess the effects of the test item “Lithium Iodide Anhydrous” on the reproductive output of Daphnia magna over a period of 48 hours under static conditions according to OECD Guideline 202 (April 2004).
Daphnia magna is a freshwater crustacean that is recommended by the OECD Guideline 202.
The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 to survival and reproduction of Daphnia magna were investigated under laboratory conditions.
Since the deviation between the measured concentrations and the nominal concentrations was withinthe range of ± 20 %, analysis of the results was based in the nominal concentrations.
The EC50 values were based on the nominal concentrations. - Results with reference substance (positive control):
- Results with positive control are conformed.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The aim of this study was to assess the effects of the test item “Lithium Iodide Anhydrous” on the immobilisation output of Daphnia magna over a period of 48 hours under static conditions according to OECD Guideline 202 (April 2004).
Daphnia magna is a freshwater crustacean that is recommended by the OECD Guideline 202. The acute effects of “Lithium Iodide Anhydrous” at the definitive theoretical concentrations of 0; 0.0625; 0.125; 0.250; 0.500 and 1.0 mg test item.L-1 were investigated under laboratory conditions.
Since the deviation between the measured concentrations and the nominal concentrations was within the range of ± 20 %, analysis of the results was based in the nominal concentrations.
The EC50 values were based on the nominal concentrations:
EC50 - 24h = 0.67mg/L
EC50 - 48h = 0.42 mg/L
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