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EC number: 432-770-2 | CAS number: 139189-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- not specified
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment of Q1 GLP compliant data
Data source
Reference
- Reference Type:
- other: written assessment
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Principles of method if other than guideline:
- No test method followed. Written assessment based on available Q1 GLP compliant data.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 432-770-2
- EC Name:
- -
- Cas Number:
- 139189-30-3
- Molecular formula:
- C38 H40 O8 P2
- IUPAC Name:
- 3-{[bis(2,6-dimethylphenoxy)phosphoryl]oxy}phenyl bis(2,6-dimethylphenyl) phosphate
- Reference substance name:
- Tetrakis (2,6-dimethylphenyl)-m-phenylene biphosphate
- IUPAC Name:
- Tetrakis (2,6-dimethylphenyl)-m-phenylene biphosphate
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
The substance is an aromatic organo-phosphorus ester of molecular weight that does not preclude absorption. No specific predictions about toxicokinetic behaviour can be made from the chemical structure. The structure suggests potential for cholinesterase inhibition, but this was specifically investigated in a repeated dose oral toxicity study with no effect identified. The substance is a non-volatile powder of non-respirable particle size, so inhalation exposure is not anticipated. Non-enzymatic hydrolysis is unlikely so exposure to degradants is not applicable.
Absorption:
Acute oral and dermal toxicity studies showed no treatment related effects and therefore provide no evidence of absorption by either route. In a repeated dose oral toxicity study also there is no significant evidence of adsorption. The substance has very high log Pow value, which would suggest ready diffusion across membranes and hence absorption. In view of the extremely low water solubility, however, this may not be a true representation of lipophilicity. Exposure in a screening reproductive toxicity test indicates no effects to parent or F1 animals and no adverse effects were indicated by mutagenicity testing.
Distribution:
There is no experimental evidence to indicate distribution except, perhaps, to the liver in the repeated dose oral toxicity study. The extremely high Pow values obtained by testing and QSAR may be suggestive of potential for accumulation, but bioaccumulation potential tends to decrease as Pow becomes increasingly high, becoming more an effect of low water solubility rather than accumulation. This observation is further borne out by the data available from fish bioaccumulation and QSAR estimations of BCF.
Metabolism:
The studies conducted provide no information about potential metabolism, but from the chemical structure, biotransformation of any absorbed substance would be expected. Ester hydrolysis by hydrolase enzymes could occur together with oxidative metabolism by the microsomal mixed function oxidase system and subsequent conjugation reactions.
Excretion:
There is no experimental evidence to indicate a route of excretion but the parent substance is not sufficiently water-soluble for elimination in its unchanged form in urine or bile, but may be eliminated in faecal matter. Biotransformation of any absorbed substance is, however, anticipated and the resulting metabolites could be eliminated either in urine, bile or faeces. As the parent substance non-volatile and could not be eliminated via the lungs in expired air.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.