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EC number: 205-440-9 | CAS number: 140-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge nitrification inhibition testing
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The SEX the subject of this dossier) is expected to exhibit very similar toxicity to Potassium ethyl xanthate (CAS No. 140-89-6), which is also xanthate compound.. Comparable metabolism would occur.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 9509 (Toxicity test for assessing the inhibition of nitrification of activated sludge microorganisms)
- Principles of method if other than guideline:
- The influence of 28 nitrification inhibitors on denitrification of nitrate in soil was studied by determining the effects of different amounts of each inhibitor on the amounts of nitrate lost and the amounts of nitrite, N2O and N2 produced when soil samples were incubated anaerobically after treatment with nitrate or with nitrate and mannitol.
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Nitrosomonas sp.
- Details on inoculum:
- Nitrosomonas
Scientific classification
Domain: Bacteria
Phylum: Proteobacteria
Class: Beta Proteobacteria
Order: Nitrosomonadales
Family: Nitrosomonadaceae
Genus: Nitrosomonas - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Hardness:
- NR
- Test temperature:
- 20 to 30°C
- pH:
- 6.0-9.0
- Dissolved oxygen:
- NR
- Salinity:
- NR
- Nominal and measured concentrations:
- 10 g g–1 soil ,50 g g–1 soil ,100 g g–1 soil.
- Reference substance (positive control):
- no
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of nitrification rate
- Remarks on result:
- other: Potassium ethyl xanthate is a nitrification inhibitor that has a been observed to inhibit soil denitrification at concentrations around 50 ppm, but only in soils previously amended with mannitol to stimulate denitrifying activity
- Details on results:
- Potassium ethyl xanthate retarded denitrification when applied at the rate of 50 g g–1 soil to soil that had been amended with mannitol to promote microbial activity.
No inhibition of denitrification was observed when this compound was applied at the rate of 10 g g–1 soil, and enhancement of denitrification was observed when it was applied at the rate of 50 or 100 g g–1 soil. - Validity criteria fulfilled:
- yes
- Conclusions:
- Potassium ethyl xanthate is a nitrification inhibitor that has been observed to inhibit soil denitrification at EC50= 50 mg/l
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Potassium ethyl xanthate (CAS No. 140-89-6), which is also xanthate compound.. Comparable metabolism would occur. - Executive summary:
Potassium ethyl xanthate retarded denitrification when applied at the rate of 50 g g–1 soil to soil that had been amended with mannitol to promote microbial activity. No inhibition of denitrification was observed when this compound was applied at the rate of 10 g g–1 soil, and enhancement of denitrification was observed when it was applied at the rate of 50 or 100 g g–1 soil.
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Potassium ethyl xanthate (CAS No. 140-89-6), which is also xanthate compound.. Comparable metabolism would occur.
- Endpoint:
- activated sludge nitrification inhibition testing
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The Microtox test for reduction of luminescence in Photobacterium phosphoreum was used. The test was carried out using the procedure described in the manual of the Beckman 2055 apparatus (1982).
- GLP compliance:
- no
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- Photobacterium phosphoreum
- Details on inoculum:
- marine bacterium
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 15 min
- Hardness:
- 90 mg CaCO3/L
- Test temperature:
- 20 ± 1 °C
- pH:
- 8.7 ± 0.2
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Nominal and measured concentrations:
- The test was carried out in sealed flasks to prevent evaporation of CS2.
The medium contained major salts, urea, Ca-glycerophosphate, dextrose and trace elements. The complete composition of the test medium is given in Van Leeuwen and Maas, Environ. Pollution A37: 105-115 (1985). - Details on test conditions:
- The test was carried out in sealed flasks to prevent evaporation of CS2.
- Reference substance (positive control):
- no
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 341 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: inhibition of bacterial luminescence
- Remarks on result:
- other: 95% C.I.: 260-448 mg/L
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 645.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Sodium ethyl xanthate
- Basis for effect:
- other: inhibition of bacterial luminescence
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 645.9mg/l. (341 x 144.19) /76.13 =645.9 mg/l
- Details on results:
- Reaction mass of SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of Reaction mass of SEX.
On a molecular weight scaled basis, the EC50 would be 645.9mg/l. (341 x 144.19) /76.13 =645.9 mg/l - Validity criteria fulfilled:
- yes
- Conclusions:
- The 15-min EC50 of CS2 for Photobacterium posphoreum luminescence was 341 mg/L.
SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
On a molecular weight scaled basis, the EC50 would be 645.9mg/l. (341 x 144.19) /76.13 =645.9 mg/l - Executive summary:
The 15-min EC50 of CS2 for Photobacterium posphoreum luminescence was 341 mg/L.
SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
On a molecular weight scaled basis, the EC50 would be 645.9mg/l. (341 x 144.19) /76.13 =645.9 mg/l
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
- Qualifier:
- according to guideline
- Guideline:
- other: A-Z test, Deutsches Einheidsverfahren DEV-L 9
- Principles of method if other than guideline:
- Measurement of oxygen consumption of activated sludge in a closed system to prevent evaporation of CS2.
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Mixed bacterial population (activated sludge).
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- NR
- Test temperature:
- 20 ± 1 °C
- pH:
- 8.7 ± 0.2
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Details on test conditions:
- not available
- Reference substance (positive control):
- not required
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 4.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 24.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Sodium ethyl xanthate
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 24.6 mg/l. (13 x 144.19) /76.13 =24.6 mg/l
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 8.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Sodium ethyl xanthate
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 8.7 mg/l. (4.6x 144.19) /76.13 =8.7 mg/l
- Details on results:
- SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
On a molecular weight scaled basis, the EC50 would be 24.6 mg/l. (13 x 144.19) /76.13 =24.6 mg/l
On a molecular weight scaled basis, the EC50 would be 8.7 mg/l. (4.6x 144.19) /76.13 =8.7 mg/l - Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 for inhibition of oxygen consumption in activated sludge by CS2 is 13 mg/L.
SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
On a molecular weight scaled basis, the EC50 would be 24.6 mg/l. (13 x 144.19) /76.13 =24.6 mg/l
On a molecular weight scaled basis, the EC50 would be 8.7 mg/l. (4.6x 144.19) /76.13 =8.7 mg/l - Executive summary:
The EC50 for inhibition of oxygen consumption in activated sludge by CS2 is 13 mg/L.
SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
On a molecular weight scaled basis, the EC50 would be 24.6 mg/l. (13 x 144.19) /76.13 =24.6 mg/l
On a molecular weight scaled basis, the EC50 would be 8.7 mg/l. (4.6x 144.19) /76.13 =8.7 mg/l
Referenceopen allclose all
The influence of 28 nitrification inhibitors on denitrification of nitrate in soil was studied by determining the effects of different amounts of each inhibitor on the amounts of nitrate lost and the amounts of nitrite, N2O and N2 produced when soil samples were incubated anaerobically after treatment with nitrate or with nitrate and mannitol.
The inhibitors used included nitrapyrin (N-Serve), etridiazole (Dwell), potassium azide, 2-amino-4-chloro-6-methylpyrimidine (AM), sulfathiazole (ST), 4-amino-1,2,4-triazole(ATC),2,4-diamino-6-trichloromethyl-s-triazine (CL-1580),potassium ethyl xanthate, guanylthiourea (ASU), 4-nitrobenzotrichloride, 4-mesylbenzotrichloride, sodium thiocarbonate (STC), phenylmercuric acetate (PMA), and dicyandiamide (DCD).Only one of the nitrification inhibitors studied (potassium azide) retarded denitrification when applied at the rate of 10 g g–1 soil, and only two (potassium azide and 2,4-diamino-6-trichloromethyl-s-triazine) inhibited denitrification when applied at the rate of 50 g g–1 soil. The other inhibitors either had no appreciable effect on denitrification, or enhanced denitrification, when applied at the rate of 10 or 50 g g–1 soil, enhancement being most marked with 3-mercapto-1,2,4-triazole. Seven of the inhibitors (potassium azide, sulfathiazole,potassium ethyl xanthate,sodium isopropyl xanthate, 4-nitrobenzotrichloride, sodium thiocarbonate, and phenylmercuric acetate) retarded denitrification when applied at the rate of 50 g g–1 soil to soil that had been amended with mannitol to promote microbial activity.Reports that nitrapyrin (N-Serve) and etridiazole (Dwell) inhibit denitrification when applied at rates as low as 0.5 g g–1 soil could not be confirmed. No inhibition of denitrification was observed when these compounds were applied at the rate of 10 g g–1 soil, and enhancement of denitrification was observed when they were applied at the rate of 50 or 100 g g–1 soil.
This study reports a 15-min EC50 of 341 mg/L (carbon disulphide (CS2) for the marine bacterium Photobacterium phosphoreum based on the results of a Microtox test.
.
Description of key information
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Potassium ethyl xanthate (CAS No. 140-89-6), which is also xanthate compound.. Comparable metabolism would occur.
Potassium ethyl xanthate is a nitrification inhibitor that has been observed to inhibit soil denitrification at EC50= 50 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 50 mg/L
- EC10 or NOEC for microorganisms:
- 10 mg/L
Additional information
The SEX, the subject of this dossier is expected to exhibit very similar toxicity to Potassium ethyl xanthate (CAS No. 140-89-6), which is also xanthate compound.. Comparable metabolism would occur.
Potassium ethyl xanthate is a nitrification inhibitor that has been observed to inhibit soil denitrification at EC50= 50 mg/l
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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