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Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 Jan to 16 Mar 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
other: Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)
Key result
Melting / freezing pt.:
207 °C
Decomposition:
yes
Decomp. temp.:
220 - 420 °C
Remarks on result:
other: two exothermic phases between approx. 220 - 310 °C and approx. 325 - 420 °C

After the melting process the test item showed two exothermic phases between approx. 220 - 310 °C and approx. 325 - 420 °C. These exothermic phases indicate transformation and decomposition.


 


Validity criteria for the measurement of the melting point:

























Target condition according to guideline:Actual condition according to the study:Validity criteria met:
The heating rate should not exceed 2 K/min.Heating rate 1 K/min.Yes
The mean of at least two measurements which are in the range of the estimated accuracy is reported as the melting temperature.Two values were determined, each in closed and open crucible.Yes
If the substance decomposes or sublimes before the melting temperature is reached, the temperature at which the effect is observed shall be reported.The test substance was heated up to a temperature of 220°C - no thermal decomposition was observed.Yes

 


 

Conclusions:
Fluocortolon-21-Valerat has a melting point at 207.0 °C.
Executive summary:

A differential thermoanalysis method (DTA/DSC) was used to determine the melting point with test method EC A.1, 'Melting / Freezing Temperature', which corresponds with OECD Guideline 102 'Melting Point / Melting range'. The sample was weighed in a crucible made of aluminium, cooled down in a DTA/DSC-system to 25 °C and then heated up to 450 °C (heating rate 5 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect was recorded. Between approx. 190 - 215 °C an endothermic phase could be detected which indicates the melting point of Fluocortolon-21-Valerat. After the melting process two exothermic phases between approx. 220 - 310 °C and between approx. 325 - 420 °C were detected. These exothermic phases indicate transformation and decomposition.

Description of key information

A differential thermoanalysis method (DTA/DSC) was used to determine the melting point with test method EC A.1, 'Melting / Freezing Temperature', which corresponds with OECD Guideline 102 'Melting Point / Melting range'.

The melting temperature of Fluocortolon-21-Valerat is determined as 207 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
207 °C

Additional information

After the melting process the substance showed two exothermic phases between approx. 220 - 310 °C and between approx. 325 - 420 °C. These exothermic phases indicate transformation and decomposition.