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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-fluoro-4-methyl-1,3,2-dioxaphospholane
- Cas Number:
- 16415-09-1
- Molecular formula:
- C3H6FO2P
- IUPAC Name:
- 2-fluoro-4-methyl-1,3,2-dioxaphospholane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- According to the Draize method, the test substance was applied 0.5 mL to the skin.
- Duration of treatment / exposure:
- Frequency and period of administration
Once a day
Frequency and period of application
Initial test: Apply twice and hold for 3 minutes and 1 hour each time. - Observation period:
- Corrosiveness was observed immediately after 1 hour of observation after applying the first patch for 3 minutes and immediately after removal applying the second patch. At that point the experiment was terminated.
- Number of animals:
- 1
- Details on study design:
- The one day before the test substance was applied, the hair on the back was removed using electric hair removal for animals to avoid scratching. Place the gauze (Daehan Medical. Co., Ltd.) to the transparent film (Tegaderm, 3M), and the test substance was evenly applied to gauze (width x length, 2 cm x 3 cm). Then after a non-irritating tape (Coban, 3M) was wound, and both sides were fixed with medical use tape (Micropore, 3M).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1h
- Reversibility:
- not specified
- Remarks on result:
- other: Test was ended after 1 hour.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: Test was ended after 1 hour.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- This study was performed to evaluate the acute dermal irritation / corrosion of the test substance OA-1300 in New Zealand White rabbits.
MSDS (Material Safety Data Sheet) toxicity information – Toxicological information of skin corrosion has been ‘No data’. In order to determine the corrosiveness, three patches of test substances were sequentially applied and observed during the initial test. Corrosiveness was observed immediately after 1 hour of observation after applying the first patch for 3 minutes and immediately after removal after applying the second patch for 1 hour. At that point the experiment was terminated.
Results were as follows;
There was no abnormality observed of clinical signs and no dead animal for observation period.
In the initial test, immediately after removing the first patch for 3 minutes, no skin reaction was observed at the site of application of the test substance. However, degree 1 edema and corrosion were observed at 1 hour after removal. Also, immediately after removal of the second patch for 1 hour, corrosion was observed at the site of application of the test substance.
Based on the results of the acute dermal irritation / corrosion of the test substance OA-1300 in New Zealand White rabbits, it was verified as ‘Category 1 (corrosive) / Sub-category 1A’ substance according to GHS (Globally Harmonized System of Classification and Labelling of Chemicals) classification.
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