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EC number: 953-797-0 | CAS number: 210300-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- The pH of the control and test substance treatment solutions ranged from 7.6 – 8.4 during the exposure. This deviation is not expected to have had an adverse impact on the study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
- Cas Number:
- 210300-09-7
- Molecular formula:
- C7H7NO4
- IUPAC Name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
Constituent 1
- Specific details on test material used for the study:
- Substance name: X696476
Lot #: XS9-109113-80 (TSN300901)
Purity: 100%
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 148 mg CaCO3/L
- Test temperature:
- 12.0 to 12.7°C
- pH:
- 7.6 to 8.4
- Dissolved oxygen:
- Dissolved Oxygen (new): 10.3 to 10.5 mg/L (100 to 102% sat)
Dissolved Oxygen (old): 6.9 to 8.2 mg/L (67 to 80% sat) - Salinity:
- Alkalinity: 160 mg CaCO3/L
- Conductivity:
- 350 μS
- Nominal and measured concentrations:
- Nominal Concentrations: 0 (control), 0.63, 1.5, 2.5, 5.0, and 10 mg/L
Mean Measured Concentrations:
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.21 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: lack of sublethal effects
- Remarks on result:
- other: highest concentration tested
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 9.21 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: highest concentration tested
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Rainbow Trout 96 h LC50: >9.21 mg/L
Rainbow Trout 96 h NOEC: 9.21 mg/L - Executive summary:
A 96-hour static-renewal test was performed according to OECD 203 with nominal test concentrations of 0 (control), 0.63, 1.5, 2.5, 5.0, and 10 mg/L. Test fish were impartially assigned to treatments by adding one fish per chamber, proceeding from the control, then low to high test substance treatments, and repeating steps as necessary until ten fish were present in each test chamber. The treatments were not replicated. Fish were transferred to new solutions after 48 hours.
Observations for mortality and sublethal responses were made at 24, 48, 72, and 96 hours. Temperature, pH, and dissolved oxygen concentration were measured in each test chamber daily. In addition, a continuous record of the temperature from the water bath was maintained. Alkalinity, hardness, and conductivity were measured in a sample of the dilution water at test initiation.
There was no mortality among control animals during the course of the study. Therefore, control animals satisfied test acceptability criteria for survival (i.e., ≥ 90% or one fish) as stated in the study protocol and the OECD 203 testing guidelines.
Based on mean measured concentrations, the estimated 24-, 48-, 72-, and 96-hour LC50 value was >9.21 mg/L, the highest concentration tested. The slope of the 96-hour concentration-response line could not be calculated. The 96-hour NOEC was 9.21 mg/L, based on mean measured concentrations and a lack of statistically significant mortality and sublethal effects at this, the highest test substance concentration.
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