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EC number: 247-196-6 | CAS number: 25707-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23-24 February 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- August 1996
- Deviations:
- yes
- Remarks:
- Please refer to 'principles of method if other than guideline'
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24. Partition Coefficient (n-Octanol/Water), High Performance Liquid Chromatography (HPLC) Method, EC Publication No. O.J. L54/1
- Version / remarks:
- 01 March 2016
- Deviations:
- yes
- Remarks:
- Please refer to 'principles of method if other than guideline'
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 13th April 2004
- Deviations:
- yes
- Remarks:
- Please refer to 'principles of method if other than guideline'
- Principles of method if other than guideline:
- Deviation to the Guidelines
According to the guidelines if a solvent other than the mobile phase is used to dissolve the test and reference substances, the mobile phase should be used for the final dilution prior to injection. However, the test item – being known to be unstable in the presence of water – was injected dissolved in acetonitrile. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 6.5
- Temp.:
- 25 °C
- Remarks on result:
- other: pH value not stated
- Details on results:
- As the retention time of test item samples was outside the range of retention times obtained for the reference items, a limit value is reported as partition coefficient.
- Conclusions:
- The log Pow of the test item was determined to be log Pow > 6.5.
- Executive summary:
In the course of this study the partition coefficient (Pow) of the test item was determined (estimated) using high performance liquid chromatography. The test item was identified by HPLC-MS analysis. The determined log Pow (10.2) is outside the applicability domain of the HPLC method (0 < log Pow < 6). The retention time of test item samples was outside the range of retention times obtained for the reference items, a limit value is reported as partition coefficient of the test item. Therefore, the log Pow of the test item is stated to be log Pow > 6.5.
Reference
Description of key information
The log Pow of the test item was determined to be log Pow > 6.5.
Key value for chemical safety assessment
Additional information
In the course of the study the partition coefficient (Pow) of the test item was determined (estimated) using high performance liquid chromatography. The test item was identified by HPLC-MS analysis. The determined log Pow (10.2) is outside the applicability domain of the HPLC method (0 < log Pow < 6). The retention time of test item samples was outside the range of retention times obtained for the reference items, a limit value is reported as partition coefficient of the test item. Therefore, the log Pow of the test item is stated to be log Pow > 6.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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