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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1939

Materials and methods

Test guideline
Qualifier:
no guideline followed
Version / remarks:
Pre-Guideline- and Pre-GLP-Study.
Principles of method if other than guideline:
2 Experiments with 9 resp. 10 Animals were conducted. Dose level from ca. 15000 - 25000 mg/kg bw.
GLP compliance:
no
Remarks:
Pre-GLP-Study
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Test 1: 15, 17.5, 20, 22.5 and 25 ml/kg
Test 2: 17.6, 18,6, 20.0, 21.4 and 22.6 ml/kg
No. of animals per sex per dose:
Test 1: 10
Test 2: 9
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
22 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion