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EC number: 410-400-0 | CAS number: 88671-89-0 SYSTHANE TECHNICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 29-May-1984 to 19-June-1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- 0.1 g of the ground amber solid test substance was applied to the corneal surface of 6 rabbits. Another 3 rabbits were treated, the eyes of these rabbits were irrigated with water for approximately 60 seconds starting 20-20 seconds after dosing. The eyelids were held open momentarily after dosing and then released gently to allow the animal to blink freely. The treated eyes were scored according to Draize's Procedure at 24, 48 and 72 hours after instillation, and at day 7, 14 and 21.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- α-n-butyl-α-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanenitrile
- EC Number:
- 410-400-0
- EC Name:
- α-n-butyl-α-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanenitrile
- Cas Number:
- 88671-89-0
- Molecular formula:
- C15H17ClN4
- IUPAC Name:
- 2-(4-chlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]hexanenitrile
- Test material form:
- liquid: viscous
- Remarks:
- solid
Constituent 1
- Specific details on test material used for the study:
- Crude myclobutanil; 95.7% purity
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Dutchland. Denver. PA.
- Age at study initiation: Young adult
- Weight at study initiation: approximately 2.0 - 3.5 kg
- Housing: Rabbits were housed individually in stainless steel cages
- Diet: Purina Laboratory Rabbit Chow
- Water: Drinking quality water was available ad libitum either by an automatic watering system or by water bottles.
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified
- Humidity (%): not specified
- Photoperiod (hrs dark / hrs light): 12-hr light/dark
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1g of the ground amber solid test substance was applied to the corneal surface
- Observation period (in vivo):
- The treated eyes were scored for signs of eye irritation at 24, 48 and 72 hours and at 7, 14 and 21 days after dose application.
- Number of animals or in vitro replicates:
- 6 males (no washing after instillation);
3 males (eyes were rinsed with water 20-30 seconds after instillation) - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: For 3 of these rabbits, the treated eyes were irrigated with water for approximately 60 seconds. The treated eyes of the rest of the rabbits were remained unwashed.
- Time after start of exposure: 20-30 seconds after dosing
SCORING SYSTEM: The severity of the ocular effects were scored according to the system of Draize (J. Pharmacol, Exp. Therap. 82, 377-390, 1944).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 5
- Max. score:
- 20
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.6
- Max. score:
- 10
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 7.8
- Max. score:
- 80
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Remarks:
- after 21 days: 1 animal with 1-2mm long blood vessel extended onto cornea; another animal: a 3 mm distinct hazy yellow area stain on the cornea
- Irritant / corrosive response data:
- For rabbits with unwashed eyes, slight to moderate irritation was observed in the cornea (6/6), iris (3/6) and conjunctiva (6/6) at 24 hours post-dosing. An uneven, pitted area was observed at the centre of the cornea of one rabbit with corneal and conjunctival effects. Test substance was noted to be present in the eyes of 3/6 rabbits, and around the eyes of the remaining 3 rabbits.
Irritation of reducing severity was present at 48 and 72 hours in the cornea (4/6 and 3/6, respectively) and conjunctiva (6/6 at both timepoints). Test substance was noted to be present around the eyes of the same 3 rabbits as before at 48 hours and in 1 rabbit at 72 hours.
At 7 days, irritation of the conjunctiva was still present in 2 rabbits. No irritation was observed at 14 and 21 days. However, a few blood vessels had extended into the cornea of one rabbit from Day 7 (one of the 3 rabbits with test material observed in the treated eye at 24 hrs) and, after dosing, a 3mm distinct hazy yellow stained area was seen on the cornea of another rabbit (one of the 3 rabbits with test material observed around the treated eye at 24, 48 and 72 hrs).
For rabbits with washed eyes, irritation was observed in all 3 animals in the conjunctiva at 24 hours, and only in 1 animal at 72 hours, respectively.
Any other information on results incl. tables
The results are included in Table 1 below.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The results of an in vivo eye irritancy test performed in rabbits indicated long-lasting effects on the eye for crude myclobutanil. Based on the duration of the ocular effects, the test substance was considered severely irritating to the eyes of rabbits (i.e., vascularization of the cornea was present at 21 days). Irrigating the exposed eyes with water for 60 seconds beginning 20 to 30 seconds after exposure prevented the corneal effects, decreased the conjunctival effects and shortened the recovery period.
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