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Diss Factsheets
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EC number: 249-528-5 | CAS number: 29232-93-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Overview of key values for environmental fate and pathways of the test substance
Endpoint | Key value for assessment | Comments |
Phototransformation in air | Estimated DT50: 0.802 hours by hydroxyl radical oxidation | Calculation, Atkinson method |
Hydrolysis | DT50: 117 days at 25˚C pH7 condition | EPA Subdivision N, section 161 -1 and EU Method C.7 guidelines |
Phototransformation in water | DT50: 0.07 days at 25˚C in nature pond water | MAFF Agchem Test guideline 12 Nousan N and a proposal of new OECD Guideline |
Biodegradation in water and sediment: simulation tests | DT50: 5.19 days at 20˚C in aerobic freshwater-sediment system | BBA Part IV 5-1 |
Biodegradation in soil | DT50: 8.3 days at 19˚C | No guideline followed |
Bioaccumulation | BCF (whole fish): 1264 | OECD TG 305 |
Adsorption/Desorption | Arithmetic mean Kfoc = 2356 L/kg | OECD TG 106 |
A number of metabolites were identified in the simulation studies on biodegradation in water/sediment and soil, as well as in the ADME studies. An overview is provided here to give guidance on the assignment of abbreviations used in the different study summaries.
Metabolite assignment | |||||
IUPAC name | Kirkpatrick 1994 | Arnold et al. 1976 | Hand 1996 | Adam 2005 | Macpherson 1998 |
2-(diethylamino)-6-methylpyrimidin-4-ol | M1 | M1 | M1 | M4 | M4 |
2-(diethylamino)-6-methylpyrimidin-4-yl dimethyl phosphate | N/A | M2 | N/A | N/A | N/A |
2-(ethylamino)-6-methylpyrimidin-4-ol | N/A | M3 | N/A | M7 | M5 |
N,N-diethyl-4-methoxy-6-methylpyrimidin-2-amine | N/A | M4 | N/A | N/A | N/A |
O-[2-(ethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl phosphorothioate | N/A | M5 | N/A | N/A | M2 |
O-(2-amino-6-methylpyrimidin-4-yl) O,O-dimethyl phosphorothioate | N/A | N/A | N/A | N/A | M3 |
2-amino-6-methylpyrimidin-4-ol | N/A | N/A | N/A | N/A | M6 |
O-[2-(ethylamino)-6-methylpyrimidin-4-yl] O-methyl hydrogen phosphorothioate | N/A | N/A | N/A | N/A | M7 |
O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O-methyl hydrogen phosphorothioate | N/A | N/A | M2 | N/A | M9 |
2-[ethyl(2-hydroxyethyl)amino]-6-methylpyrimidin-4-yl dimethyl phosphate | N/A | N/A | N/A | N/A | M10 |
O-{2-[ethyl(2-hydroxyethyl)amino]-6-methylpyrimidin-4-yl} O-methyl hydrogen phosphorothioate | N/A | N/A | N/A | N/A | M15 |
2-(ethylamino)-6-methylpyrimidin-4-yl dimethyl phosphate | N/A | N/A | N/A | N/A | M16 |
N,N-diethylguanidine | N/A | N/A | N/A | M5 | N/A |
N-(N,N,N'-triethylcarbamimidoyl)acetamide | N/A | N/A | N/A | M11a | N/A |
N-ethylguanidine | N/A | N/A | N/A | M11b | N/A |
2-(diethylamino)-5-methyl-4H-imidazol-4-ol | N/A | N/A | N/A | M12 | N/A |
N/A: not applicable, i.e., not identified in the study |
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