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EC number: 260-300-4 | CAS number: 56634-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Jul - 17 Aug 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 1987
- Deviations:
- yes
- Remarks:
- No details regarding environmental conditions.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-dibromo-4-cyanophenyl heptanoate
- EC Number:
- 260-300-4
- EC Name:
- 2,6-dibromo-4-cyanophenyl heptanoate
- Cas Number:
- 56634-95-8
- Molecular formula:
- C14H15Br2NO2
- IUPAC Name:
- 2,6-dibromo-4-cyanophenyl heptanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley, Inc., Houston, Texas
- Females nulliparous and non-pregnant: yes
- Age at study initiation: young adults
- Weight at study initiation: 234 - 309 g (males), 175 - 198 g (females)
- Fasting period before study: for at least 16 hours prior to treatment
- Housing: 1 - 3 per cage (separated by sex) suspended, wire bottom, stainless steel cages
- Diet: Purina Formulab Chow #5008, ad libitum
- Water: tap water, ad libitum
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES: From: 19 Jul To: 17 Aug 1989
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The dose was administered by gavage using an appropriately sized syringe and stainless steel ball-tipped intubation needle. The animals were returned to their cages immediately after treatment.
- Doses:
- 249, 500 and 750 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: three times on the day of treatment and at least once daily thereafter
- Frequency of weighing: just prior to treatment and on Days 7 and 14, or at the time of discovery after death
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes - Statistics:
- None
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 362.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 193.2 - 679.8
- Remarks on result:
- other: Mortality occurred starting from the lowest tested dose level of 249 mg/kg bw.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 291.9 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 157.1 - 542.1
- Remarks on result:
- other: Mortality occurred starting from the lowest tested dose level of 249 mg/kg bw.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 322.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 219.5 - 473.3
- Remarks on result:
- other: both sexes combined
- Mortality:
- - 249 mg/kg bw: 2/5 males and 2/5 females died (males: both on Day 1, females: 1 in the first 6 h after treatment, 1 on Day 2)
- 500 mg/kg bw/day: 2/5 males and 4/5 females died (all deaths occurred during the first 6 h after treatment, except 1 male which died on Day 1)
- 750 mg/kg bw: 5/5 males and 5/5 females died (all males died within 3 h after treatment, all females on Day 1) - Clinical signs:
- other: - 249 mg/kg bw: signs of salivation, lacrimation and nasal discharge, piloerection (reversible within 4 days), activity decrease (reversible within 1 day) - 500 mg/kg bw: signs of lacrimation, nasal discharge and salivation, signs of nasal discharge, pilo
- Gross pathology:
- A gross pathological examination was conducted on each animal which died during the study and on each animal which survived through termination of the study. Of the gross pathological findings noticed, those described as signs of lacrimation, nasal discharge, polyuria, and salivation; discoloration of the contents of the gastrointestinal tract, discoloration of the lungs, gastrointestinal tract distended with gas, large intestine empty, and variations thereof were considered possibly related to the treatment.
Summarized results can be found in Attachment 1.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The study was conducted under GLP conditions, according to U.S. EPA guideline No. 81-1, which in principle is similar to the OECD test guideline 401. The resulting LD50 for male and female rats was 362 and 292 mg/kg bw, respectively; the combined LD50 was 322.4 mg/kg bw. Taking into account the most sensitive LD50 value of 292 mg/kg bw which refers to female rats, the substance is to be classified in Cat 3 according to the criteria of the the CLP Regulation (EU) No. 1272/2008.
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