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EC number: 247-074-2 | CAS number: 25524-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 February 1994 - 31 March 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one
- EC Number:
- 247-074-2
- EC Name:
- (Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one
- Cas Number:
- 25524-95-2
- Molecular formula:
- C10H16O2
- IUPAC Name:
- (Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one
- Test material form:
- liquid
- Details on test material:
- Identification: JASMINLACTONE
Chemical name: (Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one
CAS number: 25524-95-2
Appearance/Physical state: Clear, colorless liquid
Lot: 8500119
Purity: 99.63%
Expiry date: 26 November 2021
Storage conditions: Approximately 4 °C, in the dark, under Nitrogen
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: 19004
- Purity: 94.5 %
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: cold and dark place.
Test animals
- Species:
- rabbit
- Strain:
- other: SPF Japanese white rabbits
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kitayama Labes Co., Ltd
- Age at study initiation: 11 weeks old
- Weight at study initiation: from 2.2 to 2.3 kg
- Housing: each of the animals was housed in a suspended aluminum cage with a wire net at the bottom of it (32W x 48D x 33H cm)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 25
- Humidity (%): 40 to 70
- Air changes (per hr): 12 times
- Photoperiod (hrs light): 12 hours a day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after the patches were removed.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: the dorsal area of the trunk of animals
- Type of wrap if used: a semipermeable soft bandage
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: After 4 hours of exposure, the test substance was wiped off with absorbent cotton saturated with mildly wam water.
OBSERVATION TIME POINTS : 1, 24, 48 and 72 hours after the patches were removed
SCORING SYSTEM:
- Method of calculation: The degrees of formation of erythema and crusts (hereinafter referred to as erythema) and edema were evaluated in accordance with the criteria stipulated in the OECD Guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Other effects:
- - Skin reaction: No irritation was observed in any animal up to 72 hours after the patches were removed.
- General state of health: No change was observed in any cases until the observation was completed.
- Body weight: No effect of the test substance was observed in any cases (Table 1).
Any other information on results incl. tables
Table 1: Individual body weights
Animal No | Before application | 72 hours after the removal of patch |
1 | 2.3 | 2.4 |
2 | 2.2 | 2.2 |
3 | 2.3 | 2.4 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test item did not cause irritation on the skin of rabbits under the conditions of this test.
- Executive summary:
A study was performed to determine the skin irritation potential of the test item. The study was performed according to OECD test guideline 404 and in compliance with GLP.
A single semi-occlusive dose of 0.5 ml of test item was applied to the skin of three SPF Japanese white female rabbits for 4 hours. Animals were observed for 72 hours.
No irritation was observed up to 72 hours after the patches were removed, hence the test item is considered not to be irritating to skin.
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