Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 269-198-6 | CAS number: 68189-42-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13-26 August 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- acetone
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- EC Number:
- 269-198-6
- EC Name:
- p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- Cas Number:
- 68189-42-4
- Molecular formula:
- C6H6NO6P.2C4H11NO3
- IUPAC Name:
- 4-nitrophenyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- Test material form:
- solid
- Details on test material:
- Batch / Lot No. 46587100
impurity 1
impurity 2
impurity 3
Constituent 1
- Specific details on test material used for the study:
- Batch No.: 46587100
Storage: Refrigerator (approx. 2-8°C)
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- >= 162 - <= 163 °C
- Atm. press.:
- >= 1 002 - <= 1 004 hPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 210 °C
Any other information on results incl. tables
During the heating phase a distinct endothermic effect was observed in the temperature range of 150-180°C, which can be assigned to the melting of the test item. The endothermic effect was directly followed by a small exothermic effect starting at a temperature of approx. 180°C with an average energy release of -20 J/g.
As the onset temperatures in both tests deviate by more than 0.5 K from their mean value of 162.51 °C, the test item has a melting range of 162-163°C.
A second exothermic effect was observed starting at a temperature of approx. 220°C with an average energy release of -290 J/g.
Measurement No. | Sample weight / mg | Onset of Effect / °C | Range of effect / °C | Weight loss / mg | Atmospheric pressure / hPa |
PN20063 | 7.72 | 163.23 | 150 – 180 (endo) | 3.86 | 1001.8 |
PN20065 | 9.53 | 161.78 | 150 – 180 (endo) | 4.57 | 1003.6 |
Optical verification using the capillary method
To verify the results of the DSC measurement, an additional measurement in a melting capillary was performed in the temperature range of 27°C to 225°C with a heating rate of 10 K/min. The test item started to melt at a temperature of approx. 140°C. At a temperature of 165°C the test item was completely molten (dark yellow liquid). At a temperature of 210°C the colour of the test item changed to orange. At a temperature of 225 °C the test item turned brown and rose inside the capillary. The test was terminated at a maximum temperature of 225 °C.
According to the observations during the test in the capillary method, the endothermic effect in the DSC measurements with open crucibles can be assigned to the melting of the test item.
Applicant's summary and conclusion
- Conclusions:
- The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a melting range of 162-163°C at atmospheric pressure (1002-1004 hPa) as determined by Differential Scanning Calorimetry and capillary method according to Regulation (EC) No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
- Executive summary:
The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a melting range of 162-163°C at atmospheric pressure (1002-1004 hPa) as determined by Differential Scanning Calorimetry and capillary method according to Regulation (EC) No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.