Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
no
Type of method:
effusion method: Knudsen cell

Test material

Constituent 1
Chemical structure
Reference substance name:
ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
Cas Number:
440667-78-7
Molecular formula:
C20H25N3O5
IUPAC Name:
ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
Test material form:
solid: particulate/powder

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#9
Temp.:
150 °C
Vapour pressure:
0.07 Pa
Key result
Test no.:
#8
Temp.:
135 °C
Vapour pressure:
0.024 Pa
Key result
Test no.:
#7
Temp.:
120 °C
Vapour pressure:
0.004 Pa

Applicant's summary and conclusion

Conclusions:
For the test substance L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 4.35 * 10-09 Pa
Vapour pressure at 25 °C: 1.08 * 10-08 Pa
The linear regression of log p vs. 1/T gave a correlation coefficient r of - 0.9934, showing good repeatability and precision. Therefore, the determination is considered as valid.