Registration Dossier
Registration Dossier
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EC number: 201-126-0 | CAS number: 78-59-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Differences in a2µ-globulins increased in male rat kidneys following treatment with several a2µ-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type a2µ-globulin
- Author:
- Saito K, Kaneko H, Isobe N, Nakatsuka I, Yoshitake A, Yamada H
- Year:
- 1 992
- Bibliographic source:
- Toxicology 76: 177-186
- Reference Type:
- other: OECD SIDS
- Title:
- 3,5,5-Trimethylcyclohex-2-enone (Isophorone), CAS No. 78-59-1
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 16
Materials and methods
- Type of study / information:
- Nephrotoxicity
- Principles of method if other than guideline:
- Male Sprague-Dawley rats were treated with 150 mg/kg test substance by gavage for 14 consecutive days. The effects of the test substance on alpha2µ-globulins in rat kidneys were examined by SDS-PAGE and immunoblotting analysis.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,5,5-trimethylcyclohex-2-enone
- EC Number:
- 201-126-0
- EC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Cas Number:
- 78-59-1
- Molecular formula:
- C9H14O
- IUPAC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Details on test material:
- Purity ≥ 97%
Constituent 1
Results and discussion
Any other information on results incl. tables
Treatment of male Sprague-Dawley rat with 150 mg/kg test substance by
gavage for 14 consecutive days resulted in a significant
intensification of a protein band corresponding to kidney-type
alpha2µ-globulin.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
