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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance used in the study report: Propinsulfonsaures Natrium, techn.
Specific details on test material used for the study:
new name: Reaction product of propargyl chloride and sodium bisulfite

Test animals

Species:
rat
Sex:
female
Details on test animals or test system and environmental conditions:
Mean body weight: 165 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
1%, 10% or 20% in water (w/v); pH: 5 - 6
Doses:
20, 79, 316, 1260, 5010 (2x), 7940 and 10000 mg/kg bw
No. of animals per sex per dose:
1, 2 resp. 4
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
approximate LD50
Effect level:
ca. 6 000 mg/kg bw
Mortality:
20, 79, 316 and 1260 mg/kg: 0/1 after 7 days; 5010 mg/kg: 1/4 after 7 days resp. 0/1 after 7 days; 7940 and 10000 mg/kg: 2/2 after 7 days
Clinical signs:
20 - 1260 mg/kg: no remarkable symptoms
5010 mg/kg: 1/5 animals diarrhea, otherwise no remarkable symptoms
7940 mg/kg: after 40 min diarrhea, giddy
10000 mg/kg: staggering and trembling, vigorous mucous diarrhea
Gross pathology:
10000 mg/kg (2 animals autopsied): organs: nothing abnormal detected; stomach: dilatation and filled with clear aqueous content, mucosa of the adenoid parts detached, hemorrhages, region of the forestomach without findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met