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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
5 male and 5 female rats were exposed for 4-hours by inhalation to the vapour obtained by passing air through the molten test substance at the concentration of 0.2 g/m3. Control group was also included in the study. The animals were observed for 14 days.
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorpyrifos
EC Number:
220-864-4
EC Name:
Chlorpyrifos
Cas Number:
2921-88-2
Molecular formula:
C9H11Cl3NO3PS
IUPAC Name:
O,O-diethyl O-3,5,6-trichloropyridin-2-yl phosphorothioate
Test material form:
solid
Specific details on test material used for the study:
Lot # EK 830616110
Purity: Not reported

Test animals

Species:
rat
Strain:
other: albino rats (HC/CFHB)
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Duration of exposure:
4 h
Concentrations:
0.2 g/m3
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Exp. duration:
4 h
Remarks on result:
other: The acute hazard associated with exposure to the vapour of the test substance is likely to be low
Mortality:
No deaths
Clinical signs:
other: During exposure, closing or partial closing of the eyes, excessive salivation, abnormal body posture, abnormal respiratory pattern and discharge from the snout. These signs were considered to be consistent with the response to a mildly irritant vapour.
Body weight:
Some rats showed a slight loss in body weight for 1 day following exposure to vapour from the test substance. Subsequently the rate of body weight gain was similar to that for the control rats.
Gross pathology:
No test substance related findings

Applicant's summary and conclusion

Conclusions:
The acute hazard associated with exposure to the vapour of the test substance is likely to be low
Executive summary:

5 male and 5 female rats were exposed for 4-hours by inhalation to the vapour obtained by passing air through the molten test substance at the concentration of 0.2 g/m3. Control group was also included in the study. The animals were observed for 14 days.

There were no deaths. During exposure, closing or partial closing of the eyes, excessive salivation, abnormal body posture, abnormal respiratory pattern and discharge from the snout. These signs were considered to be consistent with the response to a mildly irritant vapour. During the observation period, all exposed rats were normal in appearance and behaviour. Some rats showed a slight loss in body weight for 1 day following exposure to vapour from the test substance. Subsequently the rate of body weight gain was similar to that for the control rats.

Food and water consumption were not affected by exposure to vapour from the test substance. No gross findings considered to be related to treatment were observed.

The acute hazard associated with exposure to the vapour of the test substance is likely to be low.