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EC number: 203-867-5 | CAS number: 111-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2-aminoethylamino)ethanol
- EC Number:
- 203-867-5
- EC Name:
- 2-(2-aminoethylamino)ethanol
- Cas Number:
- 111-41-1
- Molecular formula:
- C4H12N2O
- IUPAC Name:
- 2-[(2-aminoethyl)amino]ethan-1-ol
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: D R. K . Thomae GMBH, D-7950 Biberach, FRG
- Weight at study initiation: males: between 181 - 191 g; females: between 169-179 g
- Fasting period before study: 16 hours before adminitration, but water was available ad libitum.
- Housing: Steenless wire mesh cages Type DK-III (Becker & co. Castrop-Rauxel, FRG ) housed in fully airconditioned rooms.
- Diet: Labordiaet, fa. Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland, ad libitum
- Water : Tap water ad libium per day
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature : 20 -24°C
- Humidity: 30-70%
- Photoperiod: 12 Hours dark/ 12 hours light
IN-LIFE DATES: From: 22 Oct 1985 To: 26 Nov 1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Aqua Dest.
- Details on oral exposure:
- DOSAGE PREPARATION:
Administration volume: 10 mL/kg
Time of day of administration: In the morning - Doses:
- 1470, 2150, 3160, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: recording of signs and symptoms, several times on the day of administration, at least once every workday. Check for mordibund and dead animals twice each workday and once on holidays .
- Weighing of the animals: at the beginning of the test and day 3, 5, 7 and 13.
- Necropsy of survivors performed: yes, gross pathological examination performed. - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 150 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 470 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Females: at 3160 and 5000 mg/kg bw all females died within 1 day. At 2150 mg/kg bw one female died during the first day after dosing. No mortality was observed at a concentration of 1470 mg/kg bw.
Males: At 3160 and 5000 mg/kg bw all males died within 1 day. At 2150 mg/kg bw 3 males died during the first day after exposure observation period of 14 days. No mortality was observed at a concentration of 1470 mg/kg bw. - Clinical signs:
- other: For both male and female rat, several clinical signs were observed at a concentration of 2150, 3160 and 5000 mg/kg bw during the first day after administration. The severe clinical signs observed were dyspnea, apathy, stagering, piloerection and poor gen
- Gross pathology:
- Animals that died during the observation period: Dilated stomach with red contents. Mucosa of the small intestine deep-red, atonic with red liquid contents. At a concentration of 5000 mg/kg bw hemorrhagic gastritis was observed.
Sacrificed animals at the end of the test: No abnormalities detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In an acute oral study with rats, performed similar to OECD guideline 423 an LD50 Female > 2150 mg/kg bw and an LD50 males> 1470 mg/kg bw was determined.
- Executive summary:
An acute toxicity study was performed similar to OECDguideline 423. Aminoethylethanolamin was administrated by oral gavage to five female rats and five male rats at 1470, 2150, 3160 and 5000 mg/kg body weight. At the two highest concentrations, all males and females died within 24 hours after dosing. At a concentration of 2150 mg/kg dw 3 male rats and 1 female rat died the first day after dosing. At a concentration of 1470 mg/kg bw no mortality occurred. The aminals that died during the test period showed a dilated stomach and deep red mucosa of the small intestines. At a concentation of 5000 mg/kg dw hemorrhagic gastritis was observed. No abnormalities were observed for the sacrificed animals at the end of the test. Based on these results, an LD50> 1470 mg/kg body weight was determined and Aminoethylethanolamin is classified catogory 4 for acute toxicity according to Regulation (EC) No 1272/2008.
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