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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Density

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
relative density
Remarks:
density
Type of information:
other: Density data have been generated for various protein families.
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Density data has been generated for various protein families. The data published in the cited book comes from 20 different protein families and they all have densities in the range from 1.32 g/mL to 1.42 g/mL. The density for invertase has not been determined but since it is a protein it is expected, with very high reliability, that invertase also has density in this range.
Principles of method if other than guideline:
Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993) .
GLP compliance:
not specified
Type of method:
other: Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993).
Key result
Type:
density
Density:
> 1.33 - < 1.42 g/cm³
Temp.:
20 °C
Remarks on result:
other: density range for 20 different proteins from different protein-families
Type:
relative density
Density:
> 1.33 - < 1.42 other: Relative density is dimensionless.
Remarks on result:
other: Relative density is dimensionless.

The Creighton review retrieved density data for structurally and functionally different proteins and found the densities all lay within the range of 1.33 to 1.42 g/mL. It can be concluded that the density of the test substance also lies within this range.

 

Conclusions:
The density of the test substance lies within the range of 1.33 to 1.42 g/mL.
Executive summary:

The Creighton review retrieved density data for structurally and functionally different proteins and found the densities all lay within the range of 1.33 to 1.42 g/mL. It can be concluded that the density of the test substance also lies within this range.

 

Description of key information

The Creighton review (W.H. Feerman & Co., 1993) retrieved density data for structurally and functionally different proteins and found the densities all lay within the range of 1.32 to 1.42 g/mL. It can be concluded that the density of the test substance also lies within this range.

 

Key value for chemical safety assessment

Relative density at 20C:
1.37

Additional information

A representative average value of 1.37 g/mL is given as the density for β-fructofuranosidase. The uncertainty is expected to be in the order of +/- 0.05 g/mL.