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EC number: 221-656-6 | CAS number: 3179-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,4-triazole-3-thiol
- EC Number:
- 221-656-6
- EC Name:
- 1,2,4-triazole-3-thiol
- Cas Number:
- 3179-31-5
- Molecular formula:
- C2H3N3S
- IUPAC Name:
- 4H-1,2,4-triazole-3-thiol
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- water and food ad libitum;
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- binder suspension (0.5%)
- Details on oral exposure:
- food withdrawal 16 h before application
- Doses:
- 1000 / 1470/ 2150/ 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- daily obervasion of animals, observation period 14 days
- Statistics:
- 95% probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 353 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 457 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 297 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dosis (mg/kg) death rate
male 1000 1/5
1470 3/5
2150 5/5
4640 5/5
female 1000 0/5
1470 3/5
2150 5/5
4640 5/5 - Clinical signs:
- other: The poisoning pattern in the two low dose groups was characterized by diarrhea and poor general health. Occasionally, moderate tremors, ruffled fur, stilts and sunken flanks were observed. After application of a dose of 1000 mg / kg, there were no symptom
- Gross pathology:
- In the autopsy of the deceased animals and intestinal mucosa and in 2 animals additionally the cecum reddened. The intestine contained aqueous, occasionally red-colored fluid. In one animal, the stomach or intestine was bloated. The spleen of one female animal in the lowest dose group was littered with 1 mm white bumps.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD 50 male: 1279 mg/kg
- Executive summary:
- 3 -Mercapto-1,2,4 -triazole was administered one-time orally to rats to determine its acute toxicity.The test product was present as a crystalline substance and was applied in an aqueous tragacanth suspension (0.5%).Using application volumes of 4.64 and 10.0 ml / kg with test substance contents of 215 to 464 mg / ml, the dosis in the male and female animals ranged from 1000 to 4640 mg / kg.
The intoxication was characterized by tremor, clonic convulsions, loss of muscle tone, generalized reflex failure, diarrhea and poor general condition.Occasionally, stilt walk, ruffled fur, sunken flanks and red-colored tears flow and strenuous breathing were observed.
Initial symptoms of poisoning occurred 1 hour after substance administration and lasted up to 5 days.Deaths occurred between 2 hours and 5 days p.appl.
A dose of 1000 mg / kg caused no signs of intoxication in female rats.
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