Registration Dossier
Registration Dossier
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EC number: 226-247-6 | CAS number: 5333-84-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity test to fish (14 days): No toxic symptoms observed at a concentration of 100 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
The 14-day-chronic toxicity of tetrahydromethylphthalic anhydride (MTHPA), of which 3 -MTHPA D4 is an isomer, to Oryzias latipes was studied under flow through conditions. Fish were exposed to control and test chemical at nominal/measured concentrations of 0 and 100 mg/L. The 14 day LC50/EC50 based on mortality was > 100 mg/L.
The 14-day NOEC was 100 mg/L. It is recognised that 14-days exposure is not currently regarded as a chronic study. Upon contact with water hydrolysis of MTHPA to the corresponding dicarboxylic acid rapidly occurs and, therefore, not long-term but acute toxicity effects are relevant, in particular changes of pH. Moreover, the available information about production and processing of MTHPA, and the uses identified, indicates that direct releases to the aquatic compartment can be excluded. With consideration of these aspects, no further testing is indicated and would not be in agreement with concerns regarding animal welfare and the use of animals for experimental purposes.
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