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Diss Factsheets
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EC number: 202-022-8 | CAS number: 90-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Minimal experimental detail and documentation. Information available in a summary document only. Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies followed acceptable procedures of the time and the results are valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-phenylpropionaldehyde-dimethyl acetal
- EC Number:
- 202-022-8
- EC Name:
- 2-phenylpropionaldehyde-dimethyl acetal
- Cas Number:
- 90-87-9
- Molecular formula:
- C11H16O2
- IUPAC Name:
- (1,1-dimethoxypropan-2-yl)benzene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Doses:
- 670, 1310, 2560, and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 1 850 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 270 - <= 2 430
- Mortality:
- At 670 mg/kg bw no mortality was observed. In the 1310, 2560, and 5000 mg/kg bw dose groups, 1, 8, and 10 animals died, respectively. All animals that died, died on day 1.
- Clinical signs:
- other: At 670 mg/kg bw no clinical signs were observed. Animals of the 1310 mg/kg bw dose group showed lethargy and labored breathing. Animals of the 2560 mg/kg bw dose group showed labored breathing, loss of righting reflex and coma. Coma was observed in animal
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Tox. Category 4
- Remarks:
- according to EU CLP Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- The acute oral toxicity test showed an LD50 of 1850 mg/kg bw.
- Executive summary:
In an acute oral toxicity study performed similar to OECD 401 (pre-OECD and GLP), 10 rats were administered the test substance orally at dose levels of 670, 1310, 2560 or 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Mortality was observed at the three highest dose levels. One, eight and ten animals died, all on the first day, in the dose groups 1310, 2560, and 5000 mg/kg bw, respectively. Clinical signs included lethargy, labored breathing, loss of righting reflex and coma. The acute oral LD50 for the test substance in rats was determined to be 1850 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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