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EC number: 221-904-3 | CAS number: 3275-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- a 40% solution of dimethylamine in water was used for the test
supplied by Fluka, 99% purity - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- the stock solutions were prepared fresh each day. The test solutions were renewed daily
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- daphnieds were feed with Chlorella pyrenoidosa
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
- Hardness:
- as CaCO3 = 260
- Test temperature:
- 20+-0.5°C
- pH:
- 8.1+-0.2
- Dissolved oxygen:
- not specified
- Nominal and measured concentrations:
- nominal: 10, 18, 32, 56, 100, 180 mg/l
control - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 95%C.L. = 42.2 - 56.5
- Reported statistics and error estimates:
- The EC50 values and their 95% confidence intervals were calculated according to Lichtfield and Wilkoxon (1949) method
- Validity criteria fulfilled:
- not specified
- Executive summary:
An EC50 value of 50 mg/l were determined in an acute 48h daphnia test according to OECD guideline 202
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled air-free. It is a flammable liquid and very unstable (see also chapter 1.2 or 5.1.2 or 13). Within seconds it reacts violently in contact with moisture or water. Aquatic toxicity tests are technically not feasible. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas. But dimethylamine is a well water soluble substance and was tested for acute aquatic toxicity.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR Test
- Version / remarks:
- Norme Experimentale N.F.T. 90-301 (1974)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- version: 4 April, 1984
Part I: the 24h EC50 acute immobilisation test (daphnia sp.) - Principles of method if other than guideline:
- to define the 24h IC50 for daphnia (immobilization concentration for 50% of the animals at 24h)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- dimethylamine as 40% aqueous solution
- Analytical monitoring:
- yes
- Details on sampling:
- at the beginning of the test
frequently checking during the test
at the end of the test - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Remarks on exposure duration:
- the exposure duration was in conformance to the prior guidelines
- Post exposure observation period:
- no
- Hardness:
- no information
- Test temperature:
- no information
- pH:
- no information
- Dissolved oxygen:
- no information
- Nominal and measured concentrations:
- no information
- Reference substance (positive control):
- not specified
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 48 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- An IC50 of 48 mg/l was determined with CL (95%) of 44-52 and S = 1.13 (slope of the efect concentration curves)
- Results with reference substance (positive control):
- no information
- Reported statistics and error estimates:
- IC50 determination according to Litchfield and Wilcoxon 1949
- Validity criteria fulfilled:
- not specified
- Executive summary:
For dimethylamine an IC50 of 48 mg/l was dertermined in an 24 h acute immobilisation test carried out according to AFNOR protocol
Referenceopen allclose all
Description of key information
Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled air-free. It is a flammable liquid and very unstable (see also chapter 1.2 or 5.1.2 or 13). Within seconds it reacts violently in contact with moisture or water. Aquatic toxicity studies ate technically not feasible. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas. But dimethylamine is a well water soluble substance and was tested for acute aquatic toxicity. For dimethylamine an EC50 value of 50 mg/l were determined in an acute 48h daphnia test according to OECD guideline 202 (Van Leeuwen 1985). In a second test (Calamari et al. 1980) an IC50 of 48 mg/l was dertermined for dimethylmine in an 24 h acute immobilisation test carried out according to AFNOR protocol
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.