2-phenylpropan-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptoms observed were recorded and reported.

GLP compliance:

no

Remarks:

pre-dates GLP guidelines

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenylpropan-1-ol

EC Number:

214-379-7

EC Name:

2-phenylpropan-1-ol

Cas Number:

1123-85-9

Molecular formula:

C9H12O

IUPAC Name:

2-phenylpropan-1-ol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

5 g/kg bw was applied neat to rabbit skin

Duration of exposure:

24 hours exposure

Doses:

5 g/kg bw

No. of animals per sex per dose:

5 animals (males and females)

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

One out of 5 animals died on day 1; thereafter during 14 days observation period no further mortality was observed

Clinical signs:

other: No skin irritation was seen.

Gross pathology:

not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 (dermal, rabbit) was found being > 5000 mg/kg bw.

Executive summary:

Five rabbits (male and female) were exposed to 5 g/kg bw during 24 hours exposure period and mortality was observed for 14 days. One animal died on day 1, but thereafter no further mortality was observed. Therefore, the LD50 was determined at >5000 mg/kg bw and no further dose groups were exposed. No skin irritation was observed during the study.