Registration Dossier
Registration Dossier
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EC number: 419-800-1 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 0.084
- Temp.:
- 20 °C
- pH:
- >= 9.56 - <= 9.89
- Type:
- log Pow
- Partition coefficient:
- -1.08
- Temp.:
- 20 °C
- pH:
- >= 9.56 - <= 9.89
- Conclusions:
- The partition coefficient as determined in a GLP compliant OECD guideline study was determined to be -1.08. The Pow value was 0.084.
Reference
Partition coefficient of test substance:
| Test Ref | Volume ratio | Vw (mL) | Vo (mL) | Cw (mL) | Co (mL) | Recovery (mg) | Aqueous pH | Pow | Log Pow |
| 1 | 1:2 | 10 | 5 | 1.327 | 135.5 | 13.94 | 9.56 | 0.102 | -0.99 |
| 2 | 1:2 | 10 | 5 | 1.279 | 127.2 | 13.42 | 9.71 | 0.100 | -1.00 |
| 3 | 1:1 | 5 | 5 | 1.204 | 87.9 | 6.46 | 9.89 | 0.073 | -1.14 |
| 4 | 1:1 | 5 | 5 | 1.236 | 99.9 | 6.68 | 9.85 | 0.081 | -1.09 |
| 5 | 1:4 | 10 | 2.5 | 0.741 | 60.2 | 7.56 | 9.60 | 0.081 | -1.09 |
| 6 | 1:4 | 10 | 2.5 | 0.731 | 49.7 | 7.44 | 9.59 | 0.068 | -1.17 |
Vw= Volume of water saturated with octanol
Vo= Volume of octanol saturated with water
Cw= Concentration of test substance in water saturated with octanol
Co= Concentration of test substance in octanol saturated withw water
Pow=Partition coefficient between octanol and water
Description of key information
The partition coefficient as determined in a GLP compliant OECD guideline study was determined to be -1.08. The Pow value was 0.084.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.08
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
