Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

The ecotoxicity data in this dossier from Substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% Substituted amino acid and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Substituted amino acid.

Additional information

The ecotoxicity data in this dossier from Substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% Substituted amino acid and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Substituted amino acid.

For substituted amino acid (2) solution, which is an industrial intermediate substance, two aquatic ecotoxicity test results are available and information on the inhibition of micro-organisms presented in activated sludge and in river water.

Based on the results of a short-term aquatic toxicity study, performed according to OECD 201 and GLP principles, substituted amino acid (2) solution inhibited growth of Pseudokirchneriella subcapitata at analytically confirmed nominal concentrations of 18 mg/L and higher. Based on biological relevance, the 72 h-NOErC was determined to be 100 mg/L. The 72 h-ErC50 and 72h-ErC10 and NOEC were determined to be >100 mg/L.

 

Based on the results of a short-term aquatic toxicity study, performed according to OECD 202 and GLP principles, substituted amino acid (2) solution showed no toxicity towards Daphnia magna in a 48 hour exposure period when tested up to a limit concentration of 100 mg/L. Therefore, the 48h-EC50 was determined to exceed an analytically confirmed nominal concentration of 100 mg/L.

 

No respiration inhibition occurred to the activated sludge and river water microorganisms present in the inoculum during the first 7 days of a ready biodegradability test at 0.834 mg a.i./L (NOEC = 0.834 mg a.i./L)