Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Apr - 14 May 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Calculation method
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a: Endpoint specific guidance
- Version / remarks:
- Version 6.0, 2017
- GLP compliance:
- no
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -2.5
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not determined
Reference
Octanol Solubility:
According to OECD Test Guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6. the octanol solubility at 20 °C of the test item DMPSA-K2 was determined to be:
cS = 278.4 mg/L
RSD = 8.1%
The partition coefficient is calculated with the determined octanol solubility of this study and the water solubility of study CSL-19-0535.04 by using following equation:
Pow = cn–octanol / cwater
Pow = (0.2784 g/L) / (79.5 g/L)
log POW = -2.5
Description of key information
log Pow = -2.5 at 20 °C (Calculation Method Fragments, OECD 105)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.5
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
