Registration Dossier
Registration Dossier
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EC number: 619-409-6 | CAS number: 99208-50-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.2
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: HPLC method used, due to instability of substance in water
- Details on results:
- Six reference substances were used. The values for log k and log POW of the reference items are :
Compound log k log Pow
2-Butanone -0.4817 0.3
Benzyl alcohol -0.2300 1.1
Acetophenone -0.0051 1.7
Nitrobenzene 0.1317 1.9
Benzene 0.3659 2.1
Toluene 0.6333 2.7
Capacity Factor, log Capacity Factor, log Pow Test Item
Measurement k log k log Pow
Measurement 1 0.7430 -0.1290 1.213
Measurement 2 0.7407 -0.1304 1.210
Measurement 3 0.7407 -0.1304 1.210
Mean 1.211
Relative Standard deviation 0.002 - Conclusions:
- The correlation log k/log Pow is good: the coefficient of determination r2 was calculated with 0.959. This value was considered as sufficiently high to use the calibration function for the determination of the log POW of the test item 10-(2,5-Dihydroxyphenyl)-10H-9-oxa-10- phospha-phenantbrene-10-oxide (DOPO-Hydroquinone).
Although area is not necessarily correlated to absolute concentration if UV detection is used, it is assumed that the test item 10-(2,5-Dihydroxyphenyl)-10H-9-oxa-10-phosphaphenantbrene-10-oxide (DOPO-Hydroquinone) consists mainly of one peak, indicating that the log Pow should be regarded as 1.2 ± 0.0 (mean ± standard deviation) at the temperature of 25.0 ± 1°C. - Executive summary:
The log Pow calculated for DOPO-HQ using HPLC method was found to be 1.2at the temperature of 25.0 ± 1°C.
Reference
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.2
- at the temperature of:
- 25 °C
Additional information
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